Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial

Journal of the American Geriatrics Society
J B SchwartzD Bikle

Abstract

To determine the dose-response relationship between 25-hydroxyvitamin D (25(OH)D) and supplemental vitamin D3 in elderly nursing home residents. Randomized double-blind investigation. Nursing home. Of 81 women (n=51) and men (n=30) (mean age 87.4±8) enrolled, 72 completed the study. Sixteen weeks of oral vitamin D3 at 800, 2,000, or 4,000 IU/d or 50,000 IU/wk. The main outcome was 25(OH)D concentrations (tandem mass spectrometry) after 16 weeks. Free 25(OH)D and intact parathyroid hormone (iPTH) were also analyzed. Safety monitoring of calcium and estimated glomerular filtration rate was performed, and adherence and clinical status were measured. 25(OH)D concentrations increased with dose (P<.001) and were higher with 50,000 IU/wk (P<.001) than other doses and with 4,000 IU/d than 800 or 2,000 IU/d, but 800 IU and 2,000 IU/d did not differ. One subject receiving 800 IU/d had concentrations less than 20 ng/mL. All subjects receiving more than 2000 IU/d had concentrations of 20 ng/mL and greater. Free 25(OH)D concentrations rose with total 25(OH) vitamin D. Total and free 25(OH)D were related to calcium concentrations; only free 25(OH)D was related to iPTH. 25(OH)D increased linearly with 800 to 4,000 IU/d and 50,000 IU/wk of vit...Continue Reading

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Citations

Jan 18, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Daniel BikleInez Schoenmakers
Feb 12, 2017·The Journal of Clinical Endocrinology and Metabolism·Albert ShiehJohn S Adams
Oct 12, 2017·American Journal of Epidemiology·Anne Marie Z JukicPamela L Lutsey
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Dec 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Malak El SabehGhada El-Hajj Fuleihan
Jan 26, 2021·Journal of Endocrinological Investigation·J VaculikJ J Stepan
Oct 24, 2021·The American Journal of Clinical Nutrition·Kevin D CashmanMairead Kennedy

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