Response of yeast and mycelial phases of Histoplasma capsulatum to amphotericin B and actinomycin D.

Antimicrobial Agents and Chemotherapy
S C CheungG S Kobayashi

Abstract

The dimorphic fungus Histoplasma capsulatum exists in two phases: a unicellular yeast form at 37 C and a mycelium at 25 C. We have found that these two phases have selective drug susceptibilities. The mycelial form of H. capsulatum was much more susceptible to the polyene antibiotic amphotericin B than the yeast form; in contrast, the yeast form was more susceptible to the antibiotic actinomycin D. The changes in susceptibility occurred early in the transition between the two phases and permitted the transitions to be blocked by sublethal concentrations of the appropriate drugs.

References

Apr 1, 1975·Journal of General Microbiology·N J RussellE F Gale
Jun 1, 1974·Journal of General Microbiology·S S CheungG Medoff
May 1, 1974·Journal of Bacteriology·R ScherrerP Gerhardt
Oct 18, 1974·Nature·C C HsuChen, D S Feingold
Dec 1, 1974·Antimicrobial Agents and Chemotherapy·J Kotler-BrajtburgG S Kobayashi

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Citations

Mar 1, 1979·Sabouraudia·D A Stetler, G Boguslawski
Aug 8, 2015·Journal of Clinical Microbiology·Kristie D GoughenourChad A Rappleye
Sep 1, 1978·Journal of Bacteriology·B MarescaG Kobayashi
May 1, 1979·Journal of Bacteriology·B MarescaG Medoff

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