Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits

International Journal of Audiology
Gavin M Bidelman, Louise Powers

Abstract

The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined. We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking. n = 13 normal-hearing listeners. I/O functions showed FFR amplitude increased with increasing stimulus presentation level between 25 and 80 dB SPL; FFR growth was steeper for tones than speech when measured at the same frequency. FFR latency decreased 4-5 ms with decreasing presentation level from 25 and 80 dB SPL but responses were ∼2 ms earlier for speech than tones. FFR amplitudes showed a 50% reduction over 6 min of recording with the strongest adaptation in the first 60 s (250 trials). Estimates of neural synchronisation revealed FFRs contained measurable phase-locking up to ∼1200-1300 Hz, slightly higher than the single neuron limit reported in animal models. Findings detail fundamental response properties that will be important for using FFRs in clinical and empiri...Continue Reading

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Citations

Apr 4, 2021·Audiology Research·Caitlin N Price, Deborah Moncrieff
Apr 17, 2021·The European Journal of Neuroscience·Jana Van CanneytTom Francart
Jul 7, 2021·Hearing Research·Vijayalakshmi EaswarRegan Flaherty
Jul 15, 2021·Ear and Hearing·Vijayalakshmi EaswarDavid Purcell

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