PMID: 8985884Dec 1, 1996Paper

Response sensitivity and voltage gain of the rod- and cone-horizontal cell synapses in dark- and light-adapted tiger salamander retina

Journal of Neurophysiology
X L Yang, S M Wu

Abstract

1. Rods, cones, and horizontal cells (HCs) were recorded in superfused, flat-mounted isolated retinas of the larval tiger salamander, Ambystoma tigrinum, under dark- and light-adapted conditions. 2. Under dark-adapted conditions, HC responses to dim 500-nm light stimuli were mediated only by rods. In the linear voltage range (near the dark potentials), the average response to a light step of 0.5 s (500 nm, 0.438 photons per micron2 per s) was 0.41 +/- 0.06 (SD) mV for rods and 1.86 +/- 0.52 mV for HCs. The step sensitivity of rods was approximately 0.94 mV per photon micron2 s, or 0.032 mV per activated rhodopsin molecule (Rh*) rod second, and the step sensitivity of HCs was approximately 4.25 +/- 1.19 mV per photon micron2 s or 0.14 +/- 0.04 mV per Rh* rod second. The chord voltage gain of the rod-HC synapse had an average value of 4.54 and a range from 2.68 to 7.32. 3. By the use of the spectral subtraction method, we found that the average cone-mediated HC response to a 750-nm light step that elicited an average cone response of 0.73 +/- 0.20 mV was 1.15 +/- 0.31 mV. The step sensitivity of cones under dark-adapted conditions was 0.0012 mV per photon micron2 s, and that of the cone-mediated-HC response was 0.0019 mV per phot...Continue Reading

Citations

Sep 24, 1998·Journal of Neurophysiology·D A Burkhardt, P K Fahey
Sep 6, 2005·The Journal of Physiology·Jian Wei XuMalcolm M Slaughter
Nov 9, 2007·Journal of Neurophysiology·Barbara Innocenti, Ruth Heidelberger
Mar 1, 2005·Visual Neuroscience·Dwight A BurkhardtMichael A Sikora
Feb 27, 2004·Journal of Neurophysiology·Dmitri E KourennyiSteven Barnes
Jun 15, 2018·F1000Research·Gordon Fain, Alapakkam P Sampath
Feb 17, 2009·Nature Neuroscience·Skyler L JackmanRichard H Kramer
Sep 30, 2010·Neurochemical Research·Yongchun YuDavid W Marshak
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ji-Jie PangSamuel M Wu

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