Response surface methodology applied to the study of the microwave-assisted synthesis of quaternized chitosan

Carbohydrate Polymers
Danilo Martins dos SantosSérgio Paulo Campana-Filho

Abstract

A quaternized derivative of chitosan, namely N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh), was synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) and chitosan (Ch) in acid medium under microwave irradiation. Full-factorial 2(3) central composite design and response surface methodology (RSM) were applied to evaluate the effects of molar ratio GTMAC/Ch, reaction time and temperature on the reaction yield, average degree of quaternization (DQ) and intrinsic viscosity ([η]) of QCh. The molar ratio GTMAC/Ch was the most important factor affecting the response variables and RSM results showed that highly substituted QCh (DQ = 71.1%) was produced at high yield (164%) when the reaction was carried out for 30min. at 85°C by using molar ratio GTMAC/Ch 6/1. Results showed that microwave-assisted synthesis is much faster (≤30min.) as compared to conventional reaction procedures (>4h) carried out in similar conditions except for the use of microwave irradiation.

References

Jul 1, 1996·International Journal of Biological Macromolecules·J DesbrièresM Rinaudo
Nov 11, 2003·Biomacromolecules·Entsar I RabeaWalter Steurbaut
Apr 28, 2005·Carbohydrate Research·Hua-Cai Ge, Deng-Ke Luo
Apr 18, 2006·International Journal of Pharmaceutics·Jie WuGuang-Hui Ma
Sep 2, 2008·Talanta·Marcos Almeida BezerraLuciane Amélia Escaleira
Jan 12, 2013·Biomacromolecules·Sriwanna SanyakamdhornHeidar-Ali Tajmir-Riahi
Apr 24, 2013·International Journal of Biological Macromolecules·P D ChethanBoja Poojary
Dec 26, 2013·International Journal of Pharmaceutics·George Dan Mogoşanu, Alexandru Mihai Grumezescu
Mar 29, 2014·Accounts of Chemical Research·Manoj B GawandeRajender S Varma
Jun 5, 2014·Chemical Reviews·Ying-Jie Zhu, Feng Chen
Aug 1, 2014·International Journal of Biological Macromolecules·Jun HuangJian-Wei Mao
Aug 11, 2015·Carbohydrate Polymers·Danilo Martins dos SantosGilberto Lucio Benedito de Aquino

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Citations

Jan 24, 2017·Colloids and Surfaces. B, Biointerfaces·Daniella S SilvaBruno Sarmento
Jul 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aurel TăbăcaruRodica Mihaela Dinică
Feb 13, 2021·International Journal of Biological Macromolecules·Daniella Souza SilvaSidney José Lima Ribeiro
Oct 9, 2019·International Journal of Biological Macromolecules·Danilo M Dos SantosDaniel S Correa
Dec 7, 2018·International Journal of Biological Macromolecules·William Marcondes FacchinattoSergio Paulo Campana-Filho
Oct 24, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yechan WonKimberly A Gray

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