Response surface modeling of ultrasound-assisted dispersive liquid-liquid microextraction for determination of benzene, toluene and xylenes in water samples: Box-Behnken design

Bulletin of Environmental Contamination and Toxicology
Mostafa Khajeh, Fatemeh Musavi Zadeh

Abstract

A simple, fast and effective pre-concentration procedure for the extraction of benzene, toluene and xylenes isomers (BTX) was developed using an ultrasound-assisted dispersive liquid-liquid microextraction coupled with gas chromatography-flame ionization detector in water samples. The effects of different experimental parameters in the extraction step including type and volume of extraction and dispersive solvents, ionic strength, extraction time and sample volume were studied using two techniques, namely one-variable-at-a-time and response surface methodology. The results of "one-variable-at-a-time" showed that the ionic strength and extraction time were not significant on the extraction efficiency. Therefore, a three-factor, three-level Box-Behnken experimental design was employed to optimize the BTX extraction. The optimal conditions were determined to be a volume of extraction solvent (chloroform) of 51 μL, volume of dispersive solvent (methanol) of 514 μL and volume of sample of 12 mL. The enrichment factors of 241.2-305.1, the limit of detections of 205-382 ng L(-1) were obtained for the BTX at the optimum conditions. In addition, the relative standard deviations for 50 μg L(-1) of the BTX in the water samples were found ...Continue Reading

References

Sep 24, 2004·Journal of Chromatography. a·A Serrano, M Gallego
Apr 1, 2006·Journal of Chromatography. a·Mohammad RezaeeSana Berijani
Mar 24, 2007·Journal of Chromatography. a·Dimitra A LambropoulouTriantafyllos A Albanis
Jul 7, 2009·Journal of Hazardous Materials·Kaan YetilmezsoyRobert J Vanderbei
Sep 11, 2010·Journal of Pharmaceutical and Biomedical Analysis·Hongyuan YanJingjing Du

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