Response surface models in the field of anesthesia: A crash course

Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists
Jing-Yang LiouChien-Kun Ting

Abstract

Drug interaction is fundamental in performing anesthesia. A response surface model (RSM) is a very useful tool for investigating drug interactions. The methodology appeared many decades ago, but did not receive attention in the field of anesthesia until the 1990s. Drug investigations typically start with pharmacokinetics, but it is the effects on the body clinical anesthesiologists really care about. Typically, drug interactions are divided into additive, synergistic, or infra-additive. Traditional isobolographic analysis or concentration-effect curve shifts are limited to a single endpoint. Response surface holds the complete package of isobolograms and concentration effect curves in one equation for a given endpoint, e.g., loss of response to laryngoscopy. As a pharmacodynamic tool, RSM helps anesthesiologists guide their drug therapy by navigating the surface. We reviewed the most commonly used models: (1) the Greco model; (2) Reduced Greco model; (3) Minto model; and (4) the Hierarchy models. Each one has its unique concept and strengths. These models served as groundwork for researchers to modify the formula to fit their drug of interest. RSM usually work with two drugs, but three-drug models can be constructed at the expe...Continue Reading

References

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Feb 22, 2014·Anesthesia and Analgesia·Chien-Kun TingDwayne R Westenskow

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Citations

Nov 9, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wei-Nung TengChien-Kun Ting
Feb 15, 2019·Minerva anestesiologica·Chien-Kun Ting
Mar 21, 2019·Journal of the Chinese Medical Association : JCMA·Jing-Yang LiouChien-Kun Ting
Apr 12, 2019·Anesthesiology·Christopher W Connor

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