Response to albuterol MDI delivered through an anti-static chamber during nocturnal bronchospasm.

Respiratory Care
Sreekala PrabhakaranLeslie Hendeles

Abstract

Decreasing electrostatic charge on valved holding chambers increases the amount of drug delivered. However, there are no data demonstrating that this increases bronchodilatation. To investigate the influence of reducing electrostatic charge on the bronchodilator response to albuterol inhaler during nocturnal bronchospasm. This randomized double-blind, double-dummy crossover study included subjects, 18-40 years old, with nocturnal bronchospasm (20% overnight decrease in peak flow on 3 of 7 nights during run-in), FEV(1) 60-80% predicted during the day, and ≥ 12% increase after albuterol. Subjects slept in the clinical research center up to 3 nights for each treatment. FEV(1) and heart rate were measured upon awakening spontaneously or at 4:00 am, and 15 min after each dose of 1, 2, and 4 cumulative puffs of albuterol via metered-dose inhaler. The drug was administered through an anti-static valved holding chamber (AeroChamber Plus Z-Stat) or a conventional valved holding chamber containing a static charge (AeroChamber Plus). Of 88 consented subjects, 11 were randomized and 7 completed the study. Most exclusions were due to lack of objective evidence of nocturnal bronchospasm. Upon awakening, FEV(1) was 44 ± 9% of predicted be...Continue Reading

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Citations

Aug 8, 2013·Therapeutic Delivery·Jennifer WongPhilip Chi Lip Kwok
Jul 15, 2015·Revue des maladies respiratoires·E GachelinUNKNOWN Paediatric Respiratory and Allergology Society (SP2A)
Jan 31, 2018·Therapeutic Advances in Respiratory Disease·Sanjeeva Dissanayake, Jason Suggett
Jun 1, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·R Andrew McIvorAlan Kaplan

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