Response to antiseizure medications in neonates with acute symptomatic seizures

Epilepsia
Hannah C GlassNeonatal Seizure Registry Study Group

Abstract

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.

References

Aug 12, 1999·The New England Journal of Medicine·M J PainterJ Alvin
Jan 15, 2011·Journal of Child Neurology·Nicholas S AbendRobert R Clancy
Dec 8, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Renée A ShellhaasRobert R Clancy
Apr 3, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tammy N TsuchidaUNKNOWN American Clinical Neurophysiology Society Critical Care Monitoring Committee
Mar 15, 2015·Lancet Neurology·Ronit M PresslerUNKNOWN NEonatal seizure treatment with Medication Off-patent (NEMO) consortium
Apr 24, 2016·The Journal of Pediatrics·Hannah C GlassUNKNOWN Neonatal Seizure Registry Study Group
Jun 1, 2017·Pediatric Neurology·Hannah C GlassUNKNOWN Neonatal Seizure Registry study group

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Citations

Jun 7, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Monica LemmonUNKNOWN Neonatal Seizure Registry
Dec 27, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Isaac MolineroSolomon L Moshé
Apr 9, 2021·Italian Journal of Pediatrics·Raffaele FalsaperlaMartino Ruggieri
Jun 15, 2021·Developmental Medicine and Child Neurology·Robert G HooperAdarsh Bhulani
Jun 4, 2021·Neurology·Courtney J WusthoffUNKNOWN Neonatal Seizure Registry Group
Aug 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Julie M ZiobroRenée A Shellhaas

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