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Response to cannabidiol in epilepsy of infancy with migrating focal seizures associated with KCNT1 mutations: An open-label, prospective, interventional study

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society

Jan 14, 2020

Kelsey PoissonMaria Roberta Cilio

Abstract

Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) is a rare, developmental and epileptic encephalopathy most commonly associated with mutations in KCNT1, a potassium channel. Polymorphous migrating focal seizures begin within 6 months of life and are pharmacoresistant to standar...read more

Mentioned in this Paper

Public Entity
Encephalopathic Epilepsy
Seizures
Infantile Severe Myoclonic Epilepsy
Disease Progression
Potassium Channel
Open Label Study
Interventional Study
KCNT1 protein, human
Lennox-Gastaut syndrome
3
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Response to cannabidiol in epilepsy of infancy with migrating focal seizures associated with KCNT1 mutations: An open-label, prospective, interventional study

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society

Jan 14, 2020

Kelsey PoissonMaria Roberta Cilio

PMID: 31926846

DOI: 10.1016/j.ejpn.2019.12.024

Abstract

Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) is a rare, developmental and epileptic encephalopathy most commonly associated with mutations in KCNT1, a potassium channel. Polymorphous migrating focal seizures begin within 6 months of life and are pharmacoresistant to standar...read more

Mentioned in this Paper

Public Entity
Encephalopathic Epilepsy
Seizures
Infantile Severe Myoclonic Epilepsy
Disease Progression
Potassium Channel
Open Label Study
Interventional Study
KCNT1 protein, human
Lennox-Gastaut syndrome
3

Similar Papers Found In These Feeds

Dravet Syndrome

Dravet syndrome, previously known as severe myoclonic epilepsy of infancy (SMEI), is a rare, catastrophic, lifelong form of epilepsy with frequent and/or prolonged seizures that are often triggered by hot temperatures or fever. Discover the latest research on Dravet syndrome here.

Selective Ion Transport in Channels & Pumps

Ion channels and pumps are central to a number of cell functions, including membrane excitability and synaptic transmission. With sophisticated imaging, these channels and pumps have been characterized as selective for the ions, sodium, potassium chloride and calcium. Here is the latest research on selection ion transport in channels and pumps.

Related Papers

Nature Reviews. Neurology

Epilepsy: Cannabidiol reduces seizure frequency in Dravet syndrome

Nature Reviews. NeurologyJune 18, 2017
Charlotte Ridler
Seizure : the Journal of the British Epilepsy Association

Epilepsy of infancy with migrating focal seizures: six patients treated with bromide

Seizure : the Journal of the British Epilepsy AssociationJuly 22, 2014
Roberto CaraballoErnesto Portuondo
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