PMID: 7372371Apr 15, 1980Paper

Response to chemotherapy of human, malignant melanoma xenografts in athymic, nude mice

International Journal of Cancer. Journal International Du Cancer
O FodstadA Pihl

Abstract

In attempts to elucidate the factors determining individual differences in response of tumors to chemotherapeutic agents, the sensitivity of six human malignant melanomas growing in athymic, nude mice was studied. Six agents, viz. DTIC, CCNU, vinblastine, procarbazine, as well as the toxic lectins abrin and ricin, were administered in maximum tolerable doses to the tumor-bearing mice. The response to treatment was expressed as tumor growth delay, i.e. the number of volume double times saved by the treatment. The xenografts had very nearly retined the morphology of the parent tumors and were histologically similar. They showed different and characteristic early growth rates and also wide variations in their response to the agents tested. Unexpectedly, in the case of DTIC, CCNU and procarbazine, the response of the xenografts proved to be inversely related to the early growth rates of the tumors. For vinblastine, abrin and ricin, no correlation between response and growth rate of the tumors was apparent. Procarbazine had the best overall effect among the agents here tested. DTIC, CCNU and vinblastine had somewhat less and about equal overall efficiency. The plant toxin abrin, which acts by inhibiting protein synthesis, was at lea...Continue Reading

References

Apr 15, 1979·International Journal of Cancer. Journal International Du Cancer·S Gundersen, O Fodstad
Jun 1, 1979·Cancer Treatment Reviews·D D Von HoffF M Muggia
Nov 1, 1979·Journal of Toxicology and Environmental Health·O FodstadA Pihl
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Citations

Nov 1, 1988·Cancer Metastasis Reviews·J MatternM Volm
Jan 1, 1984·Cancer Chemotherapy and Pharmacology·A GodalA Pihl
Jan 1, 1984·Archives of Oto-rhino-laryngology·B J BraakhuisG B Snow
Jan 1, 1981·The Japanese Journal of Surgery·T TaniT Hattori
Jan 1, 1981·Pharmacology & Therapeutics·S Olsnes, A Pihl
Jan 1, 1991·Acta Oto-laryngologica·U K Zätterström, J Wennerberg
Jan 1, 1990·Acta Oncologica·K M Tveit, L Ottestad
Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·A GodalO Fodstad
Mar 1, 1988·European Journal of Cancer & Clinical Oncology·E BovenH M Pinedo
Sep 1, 1982·Cell and Tissue Kinetics·E K RofstadT Lindmo
Mar 15, 1988·International Journal of Cancer. Journal International Du Cancer·O FodstadA Pihl
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·F FujitaT Hirai
Apr 15, 1986·International Journal of Cancer. Journal International Du Cancer·S AamdalA Pihl
May 15, 1982·International Journal of Cancer. Journal International Du Cancer·K M TveitA Pihl
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·K M TveitA Pihl
Sep 15, 1981·International Journal of Cancer. Journal International Du Cancer·K M TveitA Pihl
Mar 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ekaterina RevskayaEkaterina Dadachova

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