Response to clozapine of rapid cycling versus non-cycling patients with a history of mania

Bipolar Disorders
Trisha SuppesThomas Carmody

Abstract

Rapid cycling (RC) bipolar disorder (BD) patients often do not respond fully to mood-stabilizers. Atypical antipsychotics including clozapine may be good candidates as an alternative mood-stabilizer for these patients. Twenty-eight treatment-resistant patients with either Bipolar Disorder Type I (n = 20), or Schizoaffective Disorder Bipolar Type (n = 8) received clozapine add-on therapy. Patients were followed for up to 1 year. Patients were seen monthly and assessed on a number of symptom domains. Fifteen of 28 patients met RC criteria. Differences between groups was non-significant for reported age of onset, age at study entry, past history of treatment or hospitalization, or diagnosis. However, significantly more women were RC. More than 80% of patients in either group showed at least some improvement over the 1-year study. Random regression analyses found the non-rapid cycling (NRC) group experienced significantly greater improvement than RC patients (p < 0.0001). Clozapine is more effective in NRC patients with a history of mania in comparison to patients with a recent history of RC.

References

Feb 1, 1992·Archives of General Psychiatry·W CoryellM Keller
Feb 1, 1974·Archives of General Psychiatry·D L Dunner, R R Fieve
Aug 1, 1993·Journal of Clinical Psychopharmacology·J R CalabreseD J Rapport
Jun 1, 1996·The American Journal of Psychiatry·J R CalabreseH Y Meltzer
Oct 6, 2000·Biological Psychiatry·S L McElroy, P E Keck
Jan 5, 2002·The American Journal of Psychiatry·John M Kane
Mar 1, 2002·Journal of Affective Disorders·J R CalabreseS Caban
May 15, 2002·The Journal of Clinical Psychiatry·Trisha SuppesUNKNOWN Texas Consensus Conference Panel on Medication Treatment of Bipolar Disorder
Jun 4, 2002·The American Journal of Psychiatry·Mauricio TohenGary A Tollefson
Sep 28, 2002·Journal of Clinical Psychopharmacology·Ana Gonzalez-PintoJ A Micó
Mar 26, 2003·Health Services Research·T Michael KashnerMadhukar Trivedi
Apr 29, 2003·The Journal of Clinical Psychiatry·A John RushUNKNOWN TMAP Research Group
Apr 29, 2003·The Journal of Clinical Psychiatry·Trisha SuppesUNKNOWN Texas Medication Algorithm Project

❮ Previous
Next ❯

Citations

Nov 10, 2006·Psychopharmacology·Sylvester Smarty, Robert L Findling
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Trisha SuppesBjörn Paulsson
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments
Nov 16, 2004·Bipolar Disorders·Paul Mackin, Allan H Young
Dec 6, 2019·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHans Jurgen Moeller
Sep 25, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Massimiliano BuoliUNKNOWN ISBD Italian Chapter Epidemiologic Group
Oct 1, 2014·CNS Spectrums·Stephen M StahlKatherine Warburton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.