Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms

Scandinavian Journal of Immunology
Z Dembic

Abstract

The immune system is seen as a guardian of tissue integrity. It would analyse the extent and quality of damage and respond adequately. If no ill effects were found, the system would ignore disturbance, but if beneficial effects were found, it could protect certain microorganisms (establishing commensalism), perhaps via regulatory cells. The Integrity hypothesis proposes three basic groups of intercellular signals for cells of all tissues and assumes that they govern communication between dendritic cells, T cells and B cells. Signal-1 would be the main information source resulting with generation of intracellular mediators that are bound to travel into the nucleus to achieve reaction. Signal-2 represents the generation of additional signal transducers representing a modifier at the level of cytosol. And, signal-3 would be a modifier at nuclear level, perhaps guarding accessibility to chromosome or genetic locus.

References

Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Dec 1, 1996·Scandinavian Journal of Immunology·Z Dembic
Nov 4, 1998·Seminars in Immunology·R Medzhitov, C A Janeway
Feb 13, 2001·Molecular Immunology·Z Dembic
Jul 6, 2001·Scandinavian Journal of Immunology·P Matzinger
Feb 28, 2002·Trends in Immunology·Robert P A WallinHans-Gustaf Ljunggren
Apr 16, 2002·Science·Polly Matzinger
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karoline W SchjetneBjarne Bogen

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Citations

Aug 22, 2006·Scandinavian Journal of Immunology·J Cunliffe
Sep 11, 2008·Scandinavian Journal of Immunology·Z Dembic

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