Response to different benznidazole doses in animal models of chronic phase Chagas disease: a critical review

Revista Da Sociedade Brasileira De Medicina Tropical
Cauê Benito ScarimChung Man Chin

Abstract

Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN). We searched literature published in PubMed and Web of Science databases, using these keywords: animal model, BZN, Chagas disease, T. cruzi, and chronic phase, with no timeframe limitations. We excluded articles involving acute phase animal models and/or those without BZN treatment. The selected studies were conducted using different BZN concentrations (10mg-100mg) involving several different periods (5-70 days). Concentrations and durations of use are directly related to side effects, but do not prevent chronic tissue lesions. BZN use during the late/chronic phases of Chagas disease is unable to eliminate amastigote forms present in infected tissues. This study ...Continue Reading

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Citations

Nov 2, 2019·Expert Opinion on Drug Discovery·Alane Beatriz VermelhoClaudiu T Supuran
Dec 18, 2019·International Journal of Biological Macromolecules·Sheila BoreikoJorge Iulek
Aug 24, 2021·Expert Opinion on Therapeutic Patents·Jabson Herber Profiro de OliveiraJosé Lamartine Soares-Sobrinho

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