PMID: 11345378May 10, 2001Paper

Response to flecainide infusion predicts long-term success of hybrid pharmacologic and ablation therapy in patients with atrial fibrillation

Journal of the American College of Cardiology
G StabileD F Vitale

Abstract

We tested the hypothesis that the response to flecainide infusion can identify patients with atrial fibrillation (AF) in whom the hybrid pharmacologic and ablation therapy reduces the recurrences of AF. Infusion of class IC anti-arrhythmic drugs may promote transformation of AF into atrial flutter. Catheter ablation of atrial flutter has been demonstrated to be highly effective in preventing recurrences of atrial flutter. Seventy-one consecutive patients with paroxysmal or chronic AF, in whom flecainide infusion (2 mg/kg body weight, intravenously) determined the transformation of AF into common atrial flutter (positive response), were randomized to receive one of the following treatments: oral pharmacologic treatment with flecainide (group A, n = 23); the hybrid treatment (catheter ablation of the inferior vena cava-tricuspid annulus isthmus, plus oral flecainide) (group B, n = 24); or catheter ablation of the isthmus only (group C, n = 24). Thirty-seven patients with a negative response to flecainide, who chose to be submitted to the hybrid treatment, were selected as the control group (group D). During a mean follow-up period of 24 +/- 7.2 months, the recurrences of AF and atrial flutter in group B (42%) were significantly l...Continue Reading

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Citations

May 3, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·John Silberbauer, Neil Sulke
May 4, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Nicholas AnastasioDavid J Callans
Nov 6, 2002·The American Journal of Geriatric Cardiology·Irina Savelieva, A John Camm
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Pietro TurcoGiuseppe Stabile
Mar 8, 2013·The American Journal of Cardiology·Susanne LöbeAndreas Bollmann
Mar 19, 2004·Journal of Cardiovascular Electrophysiology·Leonardo CalòMassimo Santini
Mar 5, 2004·Cardiology Clinics·Maurits C E F Wijffels, Harry J G M Crijns
Jul 22, 2014·International Journal of Cardiology·Javier García SearaJosé Ramón González Juanatey
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Sep 25, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paulus KirchhofKatja Zeppenfeld
Oct 14, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Malini GovindanA John Camm
Dec 22, 2011·Yonsei Medical Journal·Jin-Bae KimSung-Soon Kim
Sep 23, 2008·Journal of Cardiovascular Pharmacology·Malini GovindanA John Camm
Oct 2, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Zi-Heng ZhengSu-Hua Wu

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