Response to Glucocorticosteroids Predicts Olfactory Outcome After ESS in Chronic Rhinosinusitis

The Laryngoscope
Vasyl BogdanovThomas Hummel

Abstract

Olfaction is frequently impaired in chronic rhinosinusitis with nasal polyps (CRSwNP) and often improves after endoscopic sinus surgery (ESS). Data about dynamics of olfactory changes after ESS are lacking, and little information is available concerning whether preoperatively administered glucocorticosteroids predict postoperative olfaction. Therefore, the aim of this study was to examine dynamics of olfaction after ESS in relation to the effect of preoperative administration of glucocorticosteroids in CRSwNP. This prospective study included 52 CRSwNP patients (30 men, 22 women, mean age 54 ± 14 years) divided into a control group (n = 31) subjected to ESS without preoperative steroids and a treatment group (n = 21) receiving orally administered glucocorticosteroids preoperatively. Self-ratings of olfaction and olfactory testing using the extended Sniffin' Sticks test battery (threshold, discrimination and identification [TDI] score) were performed. Olfaction was measured preoperatively; after termination of glucocorticosteroid treatment (only treatment group); and 2 weeks, 1 month, and 3 months postoperatively. After glucocorticosteroids, TDI score significantly improved in 57% of patients, and olfactory function remained unch...Continue Reading

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Citations

May 29, 2020·Current Allergy and Asthma Reports·Mikkel Christian Alanin, Claire Hopkins
Aug 2, 2020·The Laryngoscope·Julien W HsiehBasile N Landis
Aug 21, 2020·Head and Neck Pathology·Jerome R LechienSven Saussez
Dec 29, 2020·Laryngoscope Investigative Otolaryngology·Xiaoguang YanThomas Hummel
Apr 13, 2020·Immunology and Allergy Clinics of North America·Omar G Ahmed, Nicholas R Rowan
Oct 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Joaquim MullolLeda P Mannent

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