Response to heat pain stimulation in idiopathic Parkinson's disease

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
R NandhagopalAlexander Jon Stoessl

Abstract

Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. The aim of this study is to assess thermal experience and emotional content, as well as side-to-side sensory differences in PD "off" and "on" dopaminergic therapy following thermal cutaneous stimulation. Cross-sectional design. University teaching hospital. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.

References

May 1, 1976·Neurology·S R SniderL J Cote
Mar 1, 1988·The International Journal of Neuroscience·R SandykR P Iacono
Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Jan 1, 1995·Pain·E H Chudler, W K Dong
Nov 1, 1996·Neurology·M E Hillen, J I Sage
Oct 14, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·K H KarlsenJ P Larsen
Aug 15, 2002·Neurology·Tatiana WitjasA Ali Chérif
Oct 29, 2003·Pain·Chantal VillemureM Catherine Bushnell
Aug 4, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Christine Brefel-CourbonOlivier Rascol
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J ScottJon-Kar Zubieta
Dec 5, 2006·Pharmacology, Biochemistry, and Behavior·T ShimizuM Nomoto
Feb 6, 2007·Nature Neuroscience·Susheel VijayraghavanAmy F T Arnsten
Jul 6, 2007·The European Journal of Neuroscience·Patrick B WoodBoris A Chizh
Nov 13, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Sean S O'SullivanAndrew J Lees
Jun 3, 2008·Brain : a Journal of Neurology·Maria NolanoLucio Santoro
Jul 26, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·V MyliusJ C Möller
Sep 10, 2008·Archives of Neurology·Giovanni DefazioMichele Tinazzi
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Kapil Sethi
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hidehiko TakahashiTetsuya Suhara
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marco L LoggiaBernard Brais
Mar 27, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Uwe EhrtDag Aarsland
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Petra SchweinhardtM Catherine Bushnell

❮ Previous
Next ❯

Citations

Nov 13, 2013·Nature Reviews. Neurology·Antonella ConteAlfredo Berardelli
Nov 10, 2011·Brain : a Journal of Neurology·David Borsook
Feb 18, 2016·Current Neurology and Neuroscience Reports·Christian GeroinMichele Tinazzi
Feb 9, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Carlo V BellieniGiuseppe Buonocore
Nov 2, 2016·Parkinson's Disease·Marcelo Rezende Young BloodCarlos Henrique Ferreira Camargo
Feb 10, 2017·Ageing Research Reviews·Trevor ThompsonBrendon Stubbs
Mar 10, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A AntoniniO Rascol
Jul 7, 2015·European Journal of Pain : EJP·R G CuryD Ciampi de Andrade
Jun 30, 2019·Disease Models & Mechanisms·Lucie ValekIrmgard Tegeder
Nov 19, 2020·Neurotoxicity Research·Francesca BiagioniFrancesco Fornai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Angélique Gerdelat-MasChristine Brefel-Courbon
Movement Disorders : Official Journal of the Movement Disorder Society
Janne GierthmühlenRalf Baron
Movement Disorders : Official Journal of the Movement Disorder Society
Shen-Yang LimAndrew H Evans
Movement Disorders : Official Journal of the Movement Disorder Society
Estelle DellapinaChristine Brefel-Courbon
© 2021 Meta ULC. All rights reserved