Response to heat treatment (42.5 degrees C) in vivo and in vitro of five human melanoma xenografts

The British Journal of Radiology
E K Rofstad, T Brustad

Abstract

The response to heat (42.5 degrees C) of five human melanoma xenografts was studied. Tumours grown subcutaneously in the hind leg of athymic mice were heated in a water-bath and specific growth delay was used as a measure of response. In other experiments, cells from the same xenografts were heated in vitro and the colony-forming ability was assayed in soft agar. The slopes of the in-vivo dose-response curves (specific growth delay versus heating time) varied within a factor of about three among the five melanomas. The Do values of the in-vitro heat survival curves ranged from 44 +/- 3 to 123 +/- 15 min. The response to heat in vivo was not positively correlated with the tumour volume-doubling time, the growth fraction, the cell loss factor or the intrinsic heat sensitivity of the tumour cells, i.e., the Do values of the in vitro heat survival curves. If the results obtained in the present work are representative for clinical practice, they indicate that the response to heat may vary considerably among tumours in different patients. This variability can probably not be predicted from measurements of cytokinetic parameters of the tumours. The lack of correlation between the response to heat in vivo and in vitro demonstrates that...Continue Reading

References

Jun 1, 1979·Cancer Treatment Reviews·S B Field, N M Bleehen
Mar 1, 1978·International Journal of Radiation Oncology, Biology, Physics·L E Gerweck, P Burlett
Apr 1, 1978·British Journal of Cancer·K NowakG G Steel
Nov 1, 1978·International Journal of Radiation Oncology, Biology, Physics·J B MarmorG M Hahn
Dec 1, 1978·The British Journal of Radiology·S A Hill, J Denekamp
Feb 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K Overgaard, J Overgaard
May 1, 1969·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A F Hermens, G W Barendsen
Jan 1, 1982·Acta Radiologica. Oncology·C E LindholmB Persson
Jan 1, 1983·British Journal of Cancer·G G SteelM J Peckham
Aug 1, 1983·International Journal of Radiation Oncology, Biology, Physics·G ArcangeliF Mauro
Jul 1, 1983·The British Journal of Radiology·F Stewart, A Begg
Sep 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R S ScottL Clay
Jan 1, 1980·Annals of the New York Academy of Sciences·J Overgaard, O S Nielsen
Jan 1, 1980·Annals of the New York Academy of Sciences·C W SongS H Levitt
Jun 1, 1981·The British Journal of Radiology·J W Hand, G ter Haar
Jun 1, 1981·The British Journal of Radiology·J W Hand
May 1, 1982·International Journal of Radiation Oncology, Biology, Physics·B R PaliwalA L Wiley
Sep 1, 1982·Cell and Tissue Kinetics·E K RofstadT Lindmo
Oct 1, 1982·British Journal of Cancer·O V SolesvikT Brustad
Oct 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J R Oleson
Dec 1, 1981·International Journal of Radiation Oncology, Biology, Physics·E K Rofstad, T Brustad
Jun 1, 1980·The British Journal of Radiology·M S Kang, C W Song

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Citations

Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·Y NishimuraM Abe
Jan 1, 1990·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P Koole, J Schipper
Oct 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·E K Rofstad, T Brustad
Aug 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E K RofstadT Brustad

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