PMID: 9659654Jul 11, 1998Paper

Response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn: relationship to baseline oxygenation

Journal of Perinatology : Official Journal of the California Perinatal Association
T A ParkerS H Abman

Abstract

We hypothesized that the magnitude of response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn would correlate with the degree of baseline hypoxemia. We performed a retrospective chart review of 15 consecutive newborn infants with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide as part of a pilot study. Oxygenation index was calculated for each patient at baseline and 0.5 and 24 hours after the start of therapy and findings were compared by repeated-measures analysis of variance. Correlation was determined between baseline oxygenation index and 24-hour change in oxygenation index. Patients had a rapid and sustained decrease in oxygenation index (66.7 +/- 14.8 vs 26.3 +/- 5.0 vs 12.9 +/- 2.8, baseline vs 0.5 hour vs 24 hours; p < 0.001) during the study period, and the change in oxygenation index was highly correlated with baseline oxygenation index (r2 = 0.98). Two patients were placed on extracorporeal membrane oxygenation support before the 24-hour time point because of overwhelming sepsis and severe cardiac dysfunction. In patients with severe persistent pulmonary hypertension of the newborn, we conclude that the clinical response to inhaled nitric oxide is most ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.