Response to Malassezia pachydermatis by peripheral blood mononuclear cells from clinically normal and atopic dogs

American Journal of Veterinary Research
D O MorrisPeter J Felsburg

Abstract

To investigate the potential cell-mediated immune response of atopic dogs to the yeast Malassezia pachydermatis and to correlate it with the type-1 hypersensitivity (humoral) response of the same population of dogs. 16 clinically normal dogs, 15 atopic dogs with Malassezia dermatitis, 5 atopic dogs with Malassezia otitis, and 7 atopic control (ie, without Malassezia dermatitis or otitis) dogs. A crude extract of M pachydermatis was extracted for use as an intradermal allergy testing reagent and for stimulation of isolated peripheral blood mononuclear cells in vitro. Flow cytometry was also used to assess cell surface antigenic determinants (CD3, CD4, CD8, CD14, CD21, CD45RA, surface immunoglobulin) on peripheral blood mononuclear cells. Atopic dogs with cytologic evidence of Malassezia dermatitis had an increased lymphocyte blastogenic response to crude M pachydermatis extract, compared with clinically normal dogs and dogs with Malassezia otitis. Atopic control dogs did not differ significantly in their responses from atopic dogs with Malassezia dermatitis or otitis. A significant correlation was not found between the lymphocyte blastogenic response and the type-1 hypersensitivity response to M pachydermatis within any of the g...Continue Reading

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Citations

Mar 8, 2006·Medical Mycology·R BondD H Lloyd
Nov 21, 2015·The Veterinary Journal·Manolis N Saridomichelakis, Thierry Olivry
Nov 26, 2015·Journal de mycologie médicale·A R KhosraviS Fahimirad
Feb 17, 2015·Veterinary Dermatology·Domenico SantoroPetra Bizikova
Jun 12, 2016·Veterinary Immunology and Immunopathology·Elizabeth A Layne, Douglas J DeBoer
Jun 18, 2020·Frontiers in Immunology·Cristina LecchiFabrizio Ceciliani
Feb 26, 2013·The Veterinary Record·Tim NuttallRichard Halliwell

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