Response to maprotiline treatment in depressive patients relationship to urinary MHPG excretion and plasma drug level

Pharmacopsychiatria
H J GaertnerU Breyer-Pfaff

Abstract

In 20 patients with primary depression the urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was determined prior to a 4-week treatment with maprotiline 125 mg/day. Reliable data were available from 16 patients and averaged 1.35 mg/24 h. There was a trend towards a negative relationship between MHPG excretion and clinical improvement as reflected by the percent reduction in Hamilton scale scores. Responders, defined as those patients with a final score of less than or equal to 6, excreted less MHPG than partial or non-responders. Plasma maprotiline levels exhibited a significant increase between treatment days 14 and 28. They did not show a significant relationship to the reduction of total Hamilton scale scores. However, final scores of symptoms pertaining to depressive retardation were significantly higher in patients with low (less than 75 ng/ml) or high (greater than 150 ng/ml) plasma levels than in those with levels in an intermediate range.

Citations

Mar 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KasperH J Möller
Jul 9, 2004·Clinical and Experimental Pharmacology & Physiology·Shu-Shong HsuChung-Ren Jan
May 13, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·C B EapC Hiemke

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