Response to methadone maintenance and counseling in antisocial patients with and without major depression

The Journal of Nervous and Mental Disease
A I AltermanG E Woody

Abstract

This study compared the treatment response of four groups of psychiatrically diverse opiate-dependent, methadone maintenance patients receiving drug counseling. The four groups were patients with no other nonsubstance abuse axis I psychiatric diagnoses (OP only; N = 65), patients with lifetime major depression (DEP; N = 60), patients with both antisocial personality disorder and lifetime major depression (APD + DEP; N = 35), and patients with only APD (APD only; N = 24). Patients were assessed at intake, during treatment, and 7 months after treatment admission. No statistically significant differences were found among the groups in treatment retention/attendance. Few significant group differences were revealed during-treatment urine screens, except that barbiturate use was more common for the APD only group. The APD only group also had significantly more positive urine screens for benzodiazepines than the other three groups at 7-month follow-up. All groups reported considerable improvement in problem level at 7 months compared with admission status. The APD only group reported fewer gains in legal and employment problems than the other groups but reported greater improvement in the drug area. Thus, there was some limited suppor...Continue Reading

References

Mar 1, 1992·The Journal of Nervous and Mental Disease·D C Hodgins, N el-Guebaly
Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Jul 1, 1991·The Journal of Nervous and Mental Disease·A I Alterman, J S Cacciola
Jan 1, 1989·Journal of Substance Abuse Treatment·V M HendriksP Geerlings
Jun 1, 1987·Archives of General Psychiatry·B J RounsavilleR E Meyer
Jul 1, 1985·The Journal of Nervous and Mental Disease·A T McLellanC P O'Brien
Nov 1, 1985·Archives of General Psychiatry·M A Schuckit
Nov 1, 1985·Archives of General Psychiatry·G E WoodyC P O'Brien
Jun 1, 1983·Archives of General Psychiatry·G E WoodyA Hole
Jan 1, 1980·The Journal of Nervous and Mental Disease·A T McLellanC P O'Brien
Mar 1, 1995·The Journal of Nervous and Mental Disease·J S CacciolaE C Snider
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·R LongabaughN Noel
Feb 1, 1994·Drug and Alcohol Dependence·A I AltermanJ R McKay

❮ Previous
Next ❯

Citations

Dec 21, 2000·Current Psychiatry Reports·G E Woody
May 8, 1998·Drug and Alcohol Dependence·A I AltermanC R Boardman
Sep 27, 2003·Journal of Substance Abuse Treatment·Gilberto GerraEmilio Sternieri
May 6, 2005·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Benedikt FischerDolly Baliunas
Oct 3, 2001·The Journal of Nervous and Mental Disease·V L KingR K Brooner
Aug 16, 2006·The Journal of Nervous and Mental Disease·Elizabeth DisneyRobert K Brooner
May 17, 2007·Substance Abuse Treatment, Prevention, and Policy·William M BurdonDavid Farabee
May 12, 2006·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Joseph WestermeyerGregory Carlson
Jun 19, 2007·Journal of Substance Abuse Treatment·Karin J NeufeldRobert K Brooner
Nov 18, 2015·BMC Psychiatry·Birgitte ThylstrupMorten Hesse
May 14, 2014·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Francisco González-SaizOscar M Lozano
Jun 16, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·G HaroG Cervera
Aug 27, 1999·The Journal of Nervous and Mental Disease·J J CeceroB J Rounsaville

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.