Response to nab-paclitaxel and nedaplatin in a heavily-metastatic thymic carcinoma: A case report

Oncology Letters
Ping ZhanLi-Ke Yu

Abstract

Metastatic thymic carcinoma is an aggressive cancer that usually responds poorly to multimodal therapies. Although surgical resection is the preferred treatment for patients with advanced or metastatic disease, the clinical prognosis is typically poor. The present study describes a 63-year-old patient with thymic carcinoma who underwent a range of antitumor treatments, including surgical resection, post-operative radiotherapy and post-operative chemotherapy with several drugs, but ultimately responded to treatment with nab-paclitaxel (nab-P) and nedaplatin. Subsequent to six cycles of nab-P and nedaplatin, the lung and peritoneal metastases decreased in size and the pleural effusion was reduced. To the best of our knowledge, this is the first study to describe the response of an advanced thymic carcinoma to nab-P chemotherapy.

References

Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A MasaokaY Fujii
Sep 10, 2003·The Annals of Thoracic Surgery·Kazuya Kondo, Yasumasa Monden
Mar 3, 2004·The Journal of Pathology·Chin-Chen PanHung Chiang
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philipp StröbelAlexander Marx
Sep 22, 2005·Surgery Today·Philipp StröbelHans Konrad Müller-Hermelink
May 2, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kiyotaka YohNagahiro Saijo
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erin R GardnerWilliam D Figg
Oct 11, 2008·Medical Oncology·Xiao-Feng LiYun-Bin Ye
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nicolas GirardPaul van Schil
May 23, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giancarlo BisagniCorrado Boni
Oct 29, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicolas GirardWilliam Pao
Oct 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eric A Engels
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Girum L LemmaPatrick J Loehrer
Feb 24, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L SchirosiG Rossi
Nov 6, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A SocinskiM F Renschler
Feb 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A SocinskiM F Renschler
Sep 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L SchirosiG Rossi

❮ Previous
Next ❯

Citations

Sep 7, 2016·International Journal of Surgery Case Reports·Nobuyasu KuriharaYoshihiro Minamiya

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.