Response to polysaccharide antigens in patients with ataxia-telangiectasia

Jornal de pediatria
Maria Cristina Guerra-MaranhãoDirceu Solé

Abstract

To analyze the production of antibodies to polysaccharide antigens in patients with ataxia-telangiectasia. We used the ELISA technique to measure the levels of IgG antibodies to serotypes 1, 3, 5, 6B, 9V and 14 of Streptococcus pneumoniae in 14 patients with ataxia-telangiectasia before and after immunization with 23-valent polysaccharide vaccine. Adequate response to individual polysaccharide can be defined as a postimmunization antibody titer equal to or greater than 1.3 microg/ml or as a minimum fourfold increase over the baseline (preimmunization) value. Six (43%) patients showed an absent response to all serotypes analyzed. Four patients showed adequate response to only one serotype, one patient to two serotypes, two patients to three serotypes and only one patient to four out of six serotypes analyzed. No patient had adequate response to all serotypes tested. Postimmunization pneumococcus IgG levels were higher than preimmunization levels to all serotypes analyzed, except for serotype 3. In spite of this, the mean postimmunization levels were lower than 1.3 microg/ml in all serotypes, except for serotype 14. Mean increment was less than four in all serotypes analyzed. Our results suggest that patients with ataxia-telangie...Continue Reading

Citations

Mar 21, 2017·Developmental Medicine and Child Neurology·Nienke J H van OsUNKNOWN A-T Study Group
Jun 29, 2010·Pediatric Pulmonology·Sharon A McGrath-MorrowHoward M Lederman
Sep 12, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rachel WarrenMichael A O'Reilly

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