PMID: 2500342May 1, 1989Paper

Response to preoperative concomitant radiochemotherapy with mitomycin C and 5-fluorouracil in advanced head and neck cancer

European Journal of Cancer & Clinical Oncology
W DobrowskyV Scheiber

Abstract

Advanced head and neck tumours have a poor prognosis due to the high frequency of local recurrence. Multimodality treatment has been shown to be effective in decreasing local recurrence. In this study, 51 patients with advanced oral and oropharyngeal carcinoma were entered in a trial of preoperative radio-chemotherapy. After exclusion of -10 protocol violations (no surgery or no chemotherapy), 41 patients remained evaluable. Chemotherapy consisted of 15 mg mitomycin C/m2 given intravenously (bolus) on day 1. 5-Fluorouracil (750 mg/m2/24 h) was infused during days 1-5 (continuous infusion for 120 h). Radiotherapy was performed simultaneously with chemotherapy beginning on day 1. A total dose of 50 Gy to the primary tumour and neck region was delivered over 5 weeks. Treatment was well tolerated. Side-effects were mainly of local character (mucositis). No severe systemic toxicity was seen. Some delayed wound healing was noted at the operation (4 weeks after irradiation). The CR rate of the primary tumours was 56% (23/41). In 39% (16/41) only histological residual tumour was found. Two patients had minor response (categorized as NR) of their tumour (macroscopic residual tumour). None had tumour progression. The response rates consi...Continue Reading

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Citations

Sep 1, 1994·European Journal of Cancer. Part B, Oral Oncology·M MerlanoM Rosso
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·B ZakotnikM Zargi
Sep 1, 1992·The Australian and New Zealand Journal of Surgery·M G Poulsen
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S Rockwell
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Dec 20, 2002·The Oncologist·Louis B HarrisonDaniel Shasha
Mar 10, 2001·Cancer Treatment Reviews·W T Bradner

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