PMID: 4595181Apr 6, 1974Paper

Response to propranolol and diazepam in somatic and psychic anxiety

British Medical Journal
P J Tyrer, M H Lader


A total of 12 chronically anxious psychiatric outpatients were treated with racemic propranolol (Inderal), diazepam (Valium), and placebo for one week each, using a balanced cross-over experimental design. Six patients had predominantly somatic anxiety, complaining mostly of bodily symptoms, and six had mainly psychic anxiety, complaining primarily of psychological symptoms. Clinical ratings of anxiety were made by patient and psychiatrist after each treatment. Though diazepam was in general more effective than propranolol or placebo in relieving anxiety, propranolol was more effective than placebo in patients with somatic anxiety but not in those with psychic anxiety. We suggest that propranolol should be reserved for patients whose anxiety symptoms are mainly somatic.


May 26, 1973·Lancet·W P McMillin
Apr 28, 1973·Lancet·P J Tyrer
Jan 20, 1973·British Medical Journal·U ThadaniS H Taylor
Apr 9, 1966·Lancet·K L Granville-Grossman, P Turner
May 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·I RamsayC Bagley
Dec 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·D Wheatley
Jul 1, 1972·British Journal of Pharmacology·M H Lader, P J Tyrer
May 1, 1966·Archives of Internal Medicine·E D FrohlichI H Page
Oct 1, 1958·The Journal of Mental Science·J M ROBERTS, M HAMILTON
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON

❮ Previous
Next ❯


Jun 1, 1992·Cardiovascular Drugs and Therapy·R FogariC Gala
Nov 10, 1976·Psychopharmacology·G D BurrowsH Stevenson
Jan 1, 1982·Psychopharmacology·S Levander, A Gillner
May 15, 1976·Experientia·R Sablé-Amplis, R Agid
Sep 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J B Dyck, F Chung
Jan 1, 1984·Journal of Psychiatric Research·P Tyrer, R Owen
Jan 1, 1984·Journal of Psychosomatic Research·A J Cooper, R V Magnus
Aug 1, 1986·Pharmacology, Biochemistry, and Behavior·L A DurelJ E Barrett
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Jan 1, 1990·Pharmacology & Therapeutics·D J Nutt
Nov 1, 1985·Journal of Affective Disorders·F K JuddT R Norman
Sep 1, 1987·Journal of Affective Disorders·P E Hayes, S C Schulz
Sep 1, 1987·Journal of Affective Disorders·B A van der Kolk
Apr 1, 1990·Psychiatry Research·V K YeraganiR Balon
Mar 1, 1986·Mutation Research·N Aruna, N B Krishnamurthy
Jan 1, 1979·General Pharmacology·I M Mazurkiewicz-Kwilecki
Jan 1, 1980·Progress in Neuro-psychopharmacology·G Debus, W Janke
Jan 1, 1995·Neurophysiologie clinique = Clinical neurophysiology·W WangM Timsit-Berthier
Jan 21, 1982·The New England Journal of Medicine
Jun 1, 1976·British Journal of Clinical Pharmacology·D O Gibbons, M Phillips
Feb 1, 1976·British Journal of Clinical Pharmacology·P J Tyrer
Aug 1, 1976·British Journal of Clinical Pharmacology·H AshtonJ W Thompson
Aug 1, 1976·British Journal of Clinical Pharmacology·J Roubicek
Jan 1, 1979·British Journal of Clinical Pharmacology·M Lader
Jan 1, 1976·Current Medical Research and Opinion·G Krishnan
Mar 1, 1984·Psychosomatics·D Wheatley
Nov 1, 1976·Progress in Cardiovascular Diseases·M E ConollyC T Dollery
Jan 1, 1985·Comprehensive Psychiatry·D J MunjackM Leonard
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Clarke, S E File
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Daiane L GebauerDiogo R Lara
Apr 17, 2012·Psychoneuroendocrinology·Marieke Soeter, Merel Kindt
Jan 1, 1975·International Journal of Psychiatry in Medicine·F H Lowy
Jan 1, 1982·The American Journal of Medicine·C O BrantiganN Joseph

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.