Response to stress in Drosophila is mediated by gender, age and stress paradigm

Stress : the International Journal on the Biology of Stress
Wendi S Neckameyer, Andres R Nieto-Romero

Abstract

All living organisms must maintain equilibrium in response to internal and external challenges within their environment. Changes in neural plasticity (alterations in neuronal populations, dendritic remodeling, and synaptic turnover) are critical components of the homeostatic response to stress, which has been strongly implicated in the onset of affective disorders. However, stress is differentially perceived depending on the type of stress and its context, as well as genetic background, age and sex; therefore, an individual's maintenance of neuronal homeostasis must differ depending upon these variables. We established Drosophila as a model to analyze homeostatic responses to stress. Sexually immature and mature females and males from an isogenic wild-type strain raised under controlled environmental conditions were exposed to four reproducible and high-throughput translatable stressors to facilitate the analysis of a large number of animals for direct comparisons. These animals were assessed in an open-field arena, in a light-dark box, and in a forced swim test, as well as for sensitivity to the sedative effects of ethanol. These studies establish that immature and mature females and males represent behaviorally distinct popul...Continue Reading

References

May 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·M J TaphoornA B Karim
Sep 1, 1990·Visual Neuroscience·H V HirschD Byers
Sep 1, 1968·Psychosomatic Medicine·J W Mason
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R J KatzB J Carroll
May 1, 1995·Harvard Review of Psychiatry·M H Teicher
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Hirth, H Reichert
Mar 8, 2000·Current Biology : CB·R J BaintonU Heberlein
Feb 26, 2003·European Journal of Pharmacology·Michel Bourin, Martine Hascoët
Jun 6, 2003·International Review of Neurobiology·Douglas J Guarnieri, Ulrike Heberlein
Aug 1, 1955·Journal of Comparative and Physiological Psychology·K C MONTGOMERY
Feb 24, 2004·Critical Reviews in Neurobiology·Philip V Holmes
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Wendi S Neckameyer, Joshua S Weinstein
Sep 19, 2006·Metabolism: Clinical and Experimental·Bruce S McEwen
Aug 10, 2007·Environmental Health Perspectives·Charles W Schmidt
Aug 24, 2007·Journal of Evolutionary Biology·S Rion, T J Kawecki
Aug 25, 2007·Journal of Sleep Research·Mariana Szklo-CoxeEmmanuel Mignot
Oct 9, 2007·Current Opinion in Psychiatry·Jerome L Kroll
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·M M C Gonzalez, G Aston-Jones
Oct 14, 2008·Sleep Medicine Reviews·Peter MeerloDennis McGinty
Jun 23, 2009·Psychoneuroendocrinology·Francesca CalabreseMarco A Riva
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Nov 9, 2010·Neuroscience and Biobehavioral Reviews·D Caroline BlanchardRobert J Blanchard
Jan 13, 2011·Current Topics in Behavioral Neurosciences·Cahir J O'Kane
Apr 5, 2011·Current Protocols in Neuroscience·Vincent CastagnéRoger D Porsolt
Aug 20, 2011·Pharmacology, Biochemistry, and Behavior·Stephanie M MillerJoseph S Lonstein
Sep 13, 2011·Expert Opinion on Therapeutic Targets·Kanwaljit ChopraVipin Arora
May 15, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Fernández-GuastiR J Handa
Aug 28, 2012·Current Topics in Behavioral Neurosciences·Jennifer Y F Lau
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anita V Devineni, Ulrike Heberlein
Jun 19, 2013·Psychopharmacology·María Belén AcevedoLinda P Spear
Jul 31, 2013·Behavioral Neuroscience·Kathryn J Argue, Wendi S Neckameyer
Oct 17, 2013·Behavioral Neuroscience·Kathryn J Argue, Wendi S Neckameyer
Nov 20, 2013·Frontiers in Neuroendocrinology·Robert J Handa, Michael J Weiser
Apr 15, 2014·Frontiers in Neuroendocrinology·Debra A Bangasser, Rita J Valentino
May 3, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathryn J Argue, Wendi S Neckameyer
Jun 3, 2014·Frontiers in Neuroendocrinology·Margaret AltemusC Neill Epperson

❮ Previous
Next ❯

Citations

Jun 12, 2016·Alcohol·Morgan L SekhonChristopher L Kliethermes
Apr 23, 2020·Stress : the International Journal on the Biology of Stress·Ana Belén Ramos-HrybMario Rafael Pagani
Jul 30, 2020·Stress : the International Journal on the Biology of Stress·Stífani Machado AraujoMarina Prigol
May 14, 2020·Scientific Reports·Maria Belenioti, Nikolaos Chaniotakis
Sep 5, 2018·Biological Trace Element Research·Paula Tais Halmenschelager, João Batista Teixeira da Rocha
Nov 11, 2020·Invertebrate Neuroscience : in·Aryana R RastiChristopher L Kliethermes
Jun 15, 2021·Disease Models & Mechanisms·Stephanie M PützThomas Raabe
Oct 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jia JiaHongtao Qin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.