Response to trametinib in recurrent low-grade serous ovarian cancer with NRAS mutation: A case report

Gynecologic Oncology Reports
Miriam ChamperDennis Yi-Shin Kuo

Abstract

Low-grade serous ovarian cancer represents a minority of ovarian cancers and has distinctive features from high grade epithelial ovarian cancer. While less aggressive, in advanced stage they can be poorly chemo-responsive and incur a treatment challenge. Next generation sequencing of tumors has allowed for the potential for targeted therapy in cancer treatment, which can allow for avoidance of traditional cytotoxic chemotherapy. We present a case of a 56 year old female with advanced recurrent low grade serous ovarian cancer found to have NRAS mutation who underwent targeted therapy with trametinib with immediate and sustained disease response. We review the response and toxicity experienced by the patient, as well as treatment for her toxicity.

References

Apr 9, 2008·American Journal of Obstetrics and Gynecology·Steven C Plaxe
May 5, 2012·Gynecologic Oncology·Ivan Diaz-PadillaAntonio Gonzalez-Martin
Jan 18, 2014·Gynecologic Oncology·Caela R MillerJohn H Farley
Oct 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Catherine EmmanuelUNKNOWN Australian Ovarian Cancer Study (AOCS)
Feb 28, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G R BlumenscheinP A Jänne

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Citations

Nov 23, 2019·Expert Opinion on Emerging Drugs·Asaf MaozKoji Matsuo
Nov 30, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ioannis A Voutsadakis
Jan 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Douglas B JohnsonKeith T Flaherty
Mar 5, 2020·Gynecologic Oncology Reports·Serena CappuccioGiovanni Scambia

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Methods Mentioned

BETA
biopsy
GTPase

Clinical Trials Mentioned

NCT02101788

Software Mentioned

FoundationOne

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