PMID: 3746385Jan 1, 1986Paper

Response variability of human brain tumors to AZQ in tissue culture

Journal of Neuro-oncology
P L KornblithC Hawkins

Abstract

In a series of 28 glioma-derived cell cultures and 6 non-gliomatous CNS tumors, AZQ has been found to have varying degrees of growth inhibiting or cytotoxic activity in nearly all lines tested at doses greater than 100 mcg/ml. At dose levels comparable to the clinically achieved levels (1 mcg/ml), AZQ was found to have a cytotoxic effect in 8 of 28 glioma-derived and 2 of 6 non-gliomatous cell lines tested. These findings suggest that AZQ has activity against certain glioma-derived cells in culture at a response ratio similar to that seen in vivo. There, appear to be significant differences in the degree of responsiveness in different patients' tumor cells which can be detected in vitro prior to clinical treatment.

References

Jan 1, 1978·Clinical Neurosurgery·P L Kornblith
Feb 1, 1979·Journal of Pharmaceutical Sciences·J S DriscollR I Geran
Apr 1, 1978·Journal of Neurosurgery·P L Kornblith, P E Szypko
Nov 1, 1976·Journal of Medicinal Chemistry·F ChouJ S Driscoll
Feb 1, 1976·Journal of Medicinal Chemistry·A H Khan, J S Driscoll
Dec 1, 1980·Journal of Cellular Physiology·P M Black, P L Kornblith
Nov 29, 1963·Science·H S SCHWARTZF S PHILIPS

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Citations

Jan 1, 1988·Journal of Neurosurgery·P L Kornblith, M Walker
Feb 28, 2002·Redox Report : Communications in Free Radical Research·P A AmstadP L Gutierrez
Jan 1, 1989·Free Radical Biology & Medicine·P L Gutierrez
Oct 1, 1987·Experimental and Molecular Pathology·M G PaggiA Floridi

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