Responses of blood glucose and serum insulin to peroral glucose load in normoglycemic twins

Acta geneticae medicae et gemellologiae
Y A KesäniemiT A Miettinen

Abstract

Fasting blood glucose and serum immunoreactive insulin (IRI) and the responses of blood glucose and serum IRI to peroral glucose challenge were investigated in middle-aged normoglycemic male twins of 17 monozygotic (MZ) and 18 dizygotic (DZ) pairs recruited from the Finnish Twin Cohort Study. Also, the role of obesity and diet in the regulation of glucose and insulin metabolism was estimated. The fasting and 2 hr postprandial (PP) glucose showed higher pairwise correlations in MZ (r = 0.78 and 0.56) than DZ (r = 0.08 and -0.05) pairs whereas fasting and PP insulin levels and the areas under the PP glucose and insulin curves were weakly and similarly correlated in MZ and DZ twins. The pairwise correlations of the 1/2 hr and 1 hr, but not the fasting and 2 hr insulin/glucose ratios, were somewhat higher in MZ (R = 0.51 and 0.53) than DZ (r = = 0.28 and 0.30) pairs. In MZ twins, the intrapair differences in the body mass index were significantly correlated with those in the fasting and 2 hr PP glucose and insulin levels and those in the fasting and 1/2 hr insulin/glucose ratios (r from 0.47 to 0.76). Also, the intrapair differences in the dietary fat calories were correlated positively, but those in the calories derived from carbo...Continue Reading

References

Dec 1, 1979·Diabetologia·D A Pyke
Jan 1, 1978·Human Heredity·S SarnaM Koskenvuo
Mar 1, 1977·The American Journal of Clinical Nutrition·J W Anderson
Aug 1, 1976·The American Journal of Clinical Nutrition·T G KiehmK Ward
Nov 25, 1972·Lancet·R B Tattersall, D A Pyke
Mar 11, 1971·The New England Journal of Medicine·J D BrunzellE L Bierman
Nov 1, 1968·Diabetes·M S Gottlieb, H F Root
Jan 1, 1980·Diabetologia·J I Mann
Feb 1, 1981·Diabetologia·A H BarnettD A Pyke
Apr 1, 1963·Acta Medica Scandinavica·B HARVALD, M HAUGE

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