Responses of cardiac natriuretic peptides after paroxysmal supraventricular tachycardia: ANP surges faster than BNP and CNP

American Journal of Physiology. Heart and Circulatory Physiology
Jen-Yuan KuoHung-I Yeh

Abstract

Atrial natriuretic peptide (ANP) secretion increases after a 30-minute of paroxysmal supraventricular tachycardia (PSVT). Whether this phenomenon also applies to brain or C-type natriuretic peptides (BNP or CNP) remains unknown. Blood samples of 18 patients (41±11 years old; 4 males) with symptomatic PSVT and normal left ventricular systolic function (ejection fraction 65±6 %) were collected from the coronary sinus (CS) and the femoral artery (FA) before and 30 minutes after the induction, and 30 minutes after the termination of PSVT. The results showed that the ANP levels rose steeply after the PSVT and then reduced at 30 minutes after the termination (baseline vs. post PSVT vs. post termination, CS: 34.0±29.6 vs. 74.1±42.3 vs. 46.1±32.9; FA: 5.9±3.24 vs. 28.2±20.7 vs. 10.0±4.6 pg/ml; all P < 0.05). In contrast, compared to ANP, the increases of BNP and CNP in CS after the PSVT were less sharp, but continued to rise after the termination of tachycardia (BNP, 10.2±6.4 vs. 11.3±7.1 vs. 11.8 ± 7.9; CNP, 4.5±1.2 vs. 4.9±1.4 vs. 5.0±1.4 pg/ml; all P < 0.05). The rise of BNP and CNP in FA was similarly less sharp after the PSVT and remained stationary after the termination. PSVT exerted differential effects on cardiac natriuretic pe...Continue Reading

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May 16, 2018·Cardiovascular Endocrinology & Metabolism·Ertan Yetkin

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