Responses of cells in the midbrain near-response area in monkeys with strabismus.

Investigative Ophthalmology & Visual Science
Vallabh E Das

Abstract

To investigate whether neuronal activity within the supraoculomotor area (SOA-monosynaptically connected to medial rectus motoneurons and encode vergence angle) of strabismic monkeys was correlated with the angle of horizontal misalignment and therefore helps to define the state of strabismus. Single-cell neural activity was recorded from SOA neurons in two monkeys with exotropia as they performed eye movement tasks during monocular viewing. Horizontal strabismus angle varied depending on eye of fixation (dissociated horizontal deviation) and the activity of SOA cells (n = 35) varied in correlation with the angle of strabismus. Both near-response (cells that showed larger firing rates for smaller angles of exotropia) and far-response (cells that showed lower firing rates for smaller angles of exotropia) cells were identified. SOA cells showed no modulation of activity with changes in conjugate eye position as tested during smooth-pursuit, thereby verifying that the responses were related to binocular misalignment. SOA cell activity was also not correlated with change in horizontal misalignment due to A-patterns of strabismus. Comparison of SOA population activity in strabismic animals and normal monkeys (described in the litera...Continue Reading

Citations

Nov 10, 2013·Investigative Ophthalmology & Visual Science·Fatema Ghasia, Lawrence Tychsen
Dec 19, 2013·Investigative Ophthalmology & Visual Science·Mark M G WaltonMichael Mustari
Nov 30, 2015·Brain Structure & Function·Paul J MayAnja K E Horn
Dec 20, 2014·Journal of Neurology·Katharina HüfnerMichael Strupp
Aug 27, 2015·The Cerebellum·Fatema F GhasiaAasef G Shaikh
Sep 3, 2016·The Journal of Comparative Neurology·Martin O BohlenPaul J May
Jul 13, 2017·The British Journal of Ophthalmology·Fatema F GhasiaAasef G Shaikh
Dec 30, 2016·Journal of Neurophysiology·Suraj UpadhyayaVallabh E Das
Apr 14, 2017·Journal of Neurophysiology·Mark M G WaltonKristina Tarczy-Hornoch
Oct 17, 2018·Investigative Ophthalmology & Visual Science·Jérome Fleuriet, Linda K McLoon
Oct 17, 2018·Investigative Ophthalmology & Visual Science·Mythri PullelaVallabh E Das
Nov 1, 2013·Asia-Pacific Journal of Ophthalmology·Iris S KassemSteven M Archer
Aug 16, 2018·Journal of Neurophysiology·Adam PallusMichael Mustari
Apr 14, 2020·Investigative Ophthalmology & Visual Science·Apoorva KarsoliaVallabh E Das
May 24, 2020·Investigative Ophthalmology & Visual Science·Adam Pallus, Mark M G Walton
Jul 8, 2020·Investigative Ophthalmology & Visual Science·Paul J May, Paul D Gamlin
May 24, 2017·Annual Review of Vision Science·Vallabh E Das
Sep 29, 2019·Investigative Ophthalmology & Visual Science·Adam PallusMark M G Walton
Oct 17, 2019·Investigative Ophthalmology & Visual Science·Suraj Upadhyaya, Vallabh E Das
Dec 26, 2019·Brain Structure & Function·Paul J MayJonathan T Erichsen
Sep 15, 2017·Journal of Neurophysiology·Mark M G Walton, Michael J Mustari
Jun 6, 2018·Frontiers in Neurology·Sarah L KangFatema F Ghasia
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Jul 15, 2021·Scientific Reports·Talora L MartinFatema F Ghasia
Nov 18, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Palak GuptaFatema F Ghasia

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