Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents

Environmental Science and Pollution Research International
Elsa BonnaféFlorence Geret

Abstract

Pharmaceutical products are a major group of chemical compounds that are continuously released into the environment. The primary pathway of pharmaceuticals to the aquatic environment is the discharge of wastewater effluents. The Psychiatric hospital of Montpon (Dordogne, France) operates with its wastewater treatment plant. We first evaluated the presence and concentrations of 27 pharmaceuticals compounds in these effluents. All of the 27 compounds were detected in these wastewater effluents at concentrations ranging between 37,500 ng L(-1) (paracetamol) and 150 ng L(-1) (citalopram). The aim of the study was then to evaluate the exposure effects of the effluents on cytochrome P450, GST, and MXR responses in Corbicula fluminea gills and digestive glands. Experiments on clams exposed during 1, 3, 7 14, and 21 days revealed a strong and continuous overexpression of mdr1 (multidrug resistant 1) gene expression in gills and transitory variations in pi-gst expression and GST activity. EROD activity increased also transitory after 1 day in the digestive gland of exposed clams. These results indicated that in the effluent, some molecules have undergone metabolism of phase 1 and/or phase 2.

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Citations

Jun 21, 2017·Ecotoxicology and Environmental Safety·M J BebiannoA C D Bainy
Jul 5, 2018·Environmental Science and Pollution Research International·Jean-Yves MazzitelliFlorence Geret
Sep 24, 2019·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Anderson Kelvin Saraiva MacêdoEnelise Marcelle Amado
Jan 8, 2021·Environmental Science and Pollution Research International·Mohamed DellaliFehmi Boufahja

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