PMID: 6163077Feb 1, 1981Paper

Responses of Fanconi anemia fibroblasts to adenine and purine analogues

Mutation Research
J H FrazelleM Swift

Abstract

Fanconi anemia (FA) fibroblasts are known to be exceptionally sensitive to the cytotoxic action of mitomycin C (MMC). The survival of FA cells was enhanced significantly when 0.5 mM caffeine or 0.5 mM adenine was added for 72 h after the cells were exposed to MMC. In other experiments in which MMC was not used, FA fibroblasts were shown to be significantly more sensitive than control cells to 6-mercaptopurine (6-MP), 6-thioguanine (6-TG), and 6-azauridine (6-AU). These observations offer a new approach to defining the basic biochemical defect in FA.

References

Jan 1, 1977·Mutation Research·J Timson
Nov 1, 1979·Journal of Cellular Physiology·R WeksbergL Siminovitch
Jul 15, 1977·Journal of Molecular Biology·Y Fujiwara, M Tatsumi
Nov 1, 1976·Journal of Cellular Physiology·E Elmore, M Swift
Dec 1, 1975·Journal of Cellular Physiology·E Elmore, M Swift
Jan 1, 1975·Cytogenetics and Cell Genetics·M M CohenG Kohn
Apr 12, 1973·The New England Journal of Medicine·L H Smith
Jul 19, 1974·Nature·P K PoonJ W Parker

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Citations

Jul 16, 1985·Biochemical and Biophysical Research Communications·M ScarpaB Dallapiccola
Jun 1, 1983·American Journal of Medical Genetics·J Cervenka, B A Hirsch

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