Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in weaned pigs

Animal : an International Journal of Animal Bioscience
M LvD W Chen

Abstract

During many pathological conditions, the tryptophan concentration in blood may be reduced. However, the effects of oxidative stress on tryptophan metabolism remain unknown. In this study, we investigated the effects of oxidative stress on growth performance and tryptophan metabolism in weaned pigs. A total of 24 weaned pigs were assigned to one of three treatments that included pigs fed ad libitum (control), pigs challenged with diquat at a dose of 10 mg/kg BW and fed ad libitum (oxidative stress) or pigs pair-fed to receive the same amount of feed as the diquat-challenged pigs. The trial lasted for 7 days. The growth performance and activities of antioxidant enzymes were declined in diquat-challenged pigs. The diquat challenge decreased the tryptophan concentration in serum and the 5-hydroxytryptamine concentration in the hypothalamus, and increased large neutral amino acids, kynurenine (Kyn) and malondialdehyde in serum. The 544-bp porcine partial mRNA sequence of the tryptophan 2,3-dioxygenase (TDO) gene was obtained according to the conserved region in the human gene sequence. In addition, the oxidative stress induced by the diquat challenge stimulated TDO-relative mRNA abundance in the liver and γ-glutamyl transpeptidase a...Continue Reading

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Citations

Jan 1, 2014·Journal of Animal Science and Biotechnology·Xiangbing MaoDaiwen Chen
Jan 20, 2016·PloS One·Jia-Qing ZhangBao-Song Xing
Jul 25, 2017·International Journal of Molecular Sciences·Kang XuYulong Yin
Aug 14, 2019·Animal : an International Journal of Animal Bioscience·F J JiY L Yin
Jun 20, 2019·Oxidative Medicine and Cellular Longevity·Jin WangWei Chen
Jun 10, 2020·Journal of Animal Science and Biotechnology·Chaoyue WenYulong Yin
May 18, 2021·Pesticide Biochemistry and Physiology·Changwon YangGwonhwa Song
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Yue HaoXianhong Gu
Aug 31, 2021·Frontiers in Veterinary Science·Jiaxin ChenDayou Shi

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