Responses of hepatocytes to DDT and methyl mercury exposure

Toxicology in Vitro : an International Journal Published in Association with BIBRA
D BussolaroC A Oliveira Ribeiro

Abstract

The aim of the current work was to investigate the effects of dichlorodiphenyltrichloroethane (DDT) and monomethyl mercury (MeHg) on hepatocytes from tropical fish Hypostomus commersoni (cascudo). In order to verify DDT and MeHg impacts on the redox milieu, cells were exposed for 4 days to 50 nM of DDT, 0.25 and 2.5 microM of MeHg and to a combination of 50 nM of DDT and 0.25 microM of MeHg. These concentrations were compared with those previously published (Filipak Neto et al., 2008) for the predator fish Hoplias malabaricus (traíra). The effects were mostly noticeable on reduced glutathione concentration and delta-aminolevulinic acid dehydratase and glutathione S-transferase activity. Catalase activity increased in the group exposed to 2.5 microM of MeHg and hydrogen peroxide levels decreased in all exposed groups. Also, superoxide anion levels decreased in the groups exposed to 2.5 microM of MeHg and DDT *MeHg group. Cell viability decreased only in the DDT exposed group, demonstrating that the antioxidant defense mechanism of H. commersoni hepatocytes is more efficient than H. malabaricus. These results corroborate the resistance of H. commersoni to polluted areas and support the hypothesis that this species is more resista...Continue Reading

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Citations

May 13, 2014·Toxicon : Official Journal of the International Society on Toxinology·Cesar Aparecido da SilvaHelena C Silva de Assis
Jul 10, 2012·Journal of Environmental Monitoring : JEM·D BussolaroC A Oliveira Ribeiro
Feb 18, 2014·Bulletin of Environmental Contamination and Toxicology·Manuela Dreyer da SilvaHelena Cristina Silva de Assis
May 24, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S LiebelF Filipak Neto
Dec 20, 2011·Journal of Environmental Monitoring : JEM·Izabella de Andrade BritoCiro Alberto de Oliveira Ribeiro
Jul 19, 2020·Chemosphere·Patricia Manuitt BritoCiro Alberto de Oliveira Ribeiro

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