Responses of lateral preoptic neurons and behavioral reactions to angiotensin II and hypertonic NaCl and sucrose administered into the rat cerebral ventricle

Electroencephalography and Clinical Neurophysiology
H P Malmo, R B Malmo

Abstract

In 18 acutely prepared rats and in 3 chronically implanted rats, multiple-unit responses of lateral preoptic area (LPOA) neurons to angiotensin II (A II) and hypertonic NaCl and sucrose injected into the lateral ventricle were recorded. In addition, behavioral reactions were observed in the chronically prepared rats. Results showed that i.vt. injections of hypertonic solutions or A II affect neural activity in the LPOA, indicating that the LPOA has connections with periventricular structures that are sensitive to these substances. Experiments with chronically implanted animals demonstrated the relevance of i.vt. injections for drinking. Some of the same solutions that produced changes in LPOA MUA in the acute series (or in anesthetized chronically implanted rats) also elicited drinking. A II was a more effective dipsogen than hypertonic NaCl, and in the strongest concentration used, NaCl produced stereotyped running, reduced head movement during quiescence, and caused a progressive fall in baseline MUA. Drinking was elicited by intermediate concentrations of i.vt. NaCl. Implications for the neuropsychology of thirst are discussed.

References

Apr 1, 1977·Electroencephalography and Clinical Neurophysiology·H P Malmo, R B Malmo
Apr 1, 1979·Electroencephalography and Clinical Neurophysiology·R B Malmo, H P Malmo
Aug 1, 1978·Journal of Comparative and Physiological Psychology·J B SimpsonJ S Camardo
Jan 1, 1979·Neuroendocrinology·W E HoffmanP G Schmid
Apr 1, 1979·Physiology & Behavior·W J Mundl, H P Malmo
Aug 1, 1979·Physiology & Behavior·W J Mundl, H P Malmo
Apr 1, 1977·Hormones and Behavior·S HsiaoJ S Camardo
Jan 1, 1975·Journal of Comparative and Physiological Psychology·R B Malmo, W J Mundl
Dec 1, 1975·Physiology & Behavior·D L Blank, M J Wayner
Mar 19, 1976·Brain Research·R B Malmo
Jan 1, 1971·Journal of Comparative and Physiological Psychology·J W Peck, D Novin
Sep 1, 1971·Journal of Comparative and Physiological Psychology·E M Blass, A N Epstein
Mar 1, 1966·Medical & Biological Engineering·W J Mundl
May 1, 1981·Neuropharmacology·W J Mudl, H P Malmo

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Citations

Oct 19, 1987·Life Sciences·R B MoffettA Husain
Aug 1, 1992·Physiology & Behavior·K M AndrewsS P Grossman
Aug 1, 1983·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R B Malmo, H P Malmo

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