PMID: 9179568May 1, 1997Paper

Responses of neurones in the medullary raphe nuclei to inputs from visceral nociceptors and the ventrolateral periaqueductal grey in the rat

Experimental Physiology
R K SnowballB M Lumb

Abstract

The ventrolateral periaqueductal grey matter (PAG) is believed to have a role in mediating cardiovascular responses to noxious visceral stimuli. The present study was carried out as a first stage in establishing whether the ventrolateral PAG may exert these influences after a relay in the caudal medullary raphe nuclei (nucleus raphe obscurus and nucleus raphe pallidus). Single unit extracellular recordings were made from neurones in the caudal raphe nuclei and, for comparison, in the more rostral nucleus raphe magnus in Saffan-anaesthetized and paralysed rats. Neurones in the mid-line medulla were tested for their responses to electrical stimulation at chemically identified depressor sites in the ventrolateral PAG and to noxious visceral stimuli (distensions of the urinary bladder and electrical stimulation of the greater splanchnic nerve). Fifty-two per cent of caudal and 74% of rostral mid-line neurones gave short latency excitatory responses to stimulation of depressor sites in the ventrolateral PAG. Of the neurones that were also tested with noxious visceral stimuli, 5% of the caudal and 47% of the rostral neurones responded to bladder distension, while 33 and 35%, respectively, of caudal and rostral neurones responded to s...Continue Reading

Citations

Sep 23, 2014·Current Hypertension Reports·Erin L O'CallaghanJulian F R Paton
Jan 20, 2004·Journal of Chemical Neuroanatomy·Jean-Pierre Hornung
Apr 14, 2011·The Journal of Physiology·E StoneT A Lovick
Nov 4, 2009·Journal of Neuroscience Research·Natalia Omelchenko, Susan R Sesack
Aug 11, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K B Thor
Feb 26, 2016·The Journal of Urology·Katelyn E Sadler, Benedict J Kolber
May 19, 2009·NeuroImage·David F Cechetto, J Kevin Shoemaker
Mar 17, 2004·The Journal of Comparative Neurology·Jane C TopolovecDavid F Cechetto
Mar 4, 2003·Journal of Neurophysiology·Thaddeus S Brink, Peggy Mason
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J R Potas, R A L Dampney
Oct 3, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Sai Sailesh Kumar Goothy, Jason McKeown
Oct 7, 2000·Autonomic Neuroscience : Basic & Clinical·E Edwards, J F Paton

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