PMID: 9160850Apr 1, 1997Paper

Responses of neurons in dorsal striatum during amphetamine-induced focused stereotypy

Psychopharmacology
G V RebecJ K Puotz

Abstract

The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first characterized in terms of their responsiveness to spontaneous movement. Various types of motor-related neurons were identified. Some increased activity above resting baseline during specific movements such as forward locomotion or turning of the head, while others were excited during periods of general behavioral activation. Neurons that showed no consistent change in firing rate during overt movement were classified separately. Administration of 5.0 mg/kg d-amphetamine caused a steady increase in the overall neuronal response through both the locomotor and stereotypy phases. An analysis of specific neuronal types, however, revealed distinct, phase-related shifts in firing rate. Locomotor-related neurons discharged rapidly during the early phase of the amphetamine response and then declined toward baseline as focused stereotypy emerged. Cells found to be excited primarily during head movements showed relatively sm...Continue Reading

Citations

Jan 24, 2002·Neurobiology of Aging·John A StanfordGreg A Gerhardt
Aug 2, 2011·Basal Ganglia·Reka Natarajan, Bryan K Yamamoto
May 28, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I Z MathewsC M McCormick
Sep 22, 2006·The European Journal of Neuroscience·François Windels, Eugene A Kiyatkin
Aug 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophia K BrieglebNancy R Zahniser
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George V Rebec
Nov 29, 2016·Frontiers in Cellular Neuroscience·Kari A Johnson, David M Lovinger
May 17, 2017·Proceedings of the National Academy of Sciences of the United States of America·Isaac D ZikeJeremy Veenstra-VanderWeele
Nov 22, 2020·Pharmacology, Biochemistry, and Behavior·Dionisio A AmodeoBryce C Ryan

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