Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases.

Neurologia Medico-chirurgica
K SakodaT Nakahara

Abstract

Pineal parenchymal tumors are so rare that their responses to radiation and/or chemotherapy are not well known. Two cases of pineocytoma, which responded well to radiation therapy and chemotherapy, are reported. A 45-year-old female received radiation therapy in a total dose of 5000 rads to the tumor. Three months after the completion of therapy, computed tomography (CT) showed complete disappearance of the tumor, and she remains well as of 1 year after treatment. The second patient, a 6-year-old girl, underwent four cycles of intravenous infusion of ACNU (25 mg) over 10 months. CT demonstrated complete disappearance of the tumor and, 18 months post-operatively, there was no evidence of tumor recurrence. The results in these two cases indicate that postoperative radiation therapy and/or chemotherapy should be strongly considered for patients with pineal parenchymal tumors.

Citations

Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·W GassmannW Mueller-Ruchholtz
May 13, 2010·Journal of Neuro-oncology·Aaron J ClarkAndrew T Parsa
Jun 25, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·A S N Jackson, P N Plowman
Feb 9, 2010·Journal of Neurosurgery·Aaron J ClarkAndrew T Parsa
Aug 2, 2011·Neurosurgery Clinics of North America·Aaron J ClarkAndrew T Parsa
Jul 24, 2004·Neurosurgery·Vivek R DeshmukhRobert F Spetzler

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