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Responses of proximal tubular cells to injury in congenital renal disease: fight or flight

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association

Apr 1, 2014

Robert L ChevalierBarbara A Thornhill

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Abstract

Most chronic kidney disease in children results from congenital or inherited disorders, which can be studied in mouse models. Following 2 weeks of unilateral ureteral obstruction (UUO) in the adult mouse, nephron loss is due to proximal tubular mitochondrial injury and cell death. In ne...read more

Mentioned in this Paper

Mitochondrial Toxicity
Cell Death
Mutant
Cyst form of protozoa
Chronic Kidney Insufficiency
Cyst
Cystine Measurement
Kidney Failure
Polycystic Kidney - Body Part
Renal Tubular Disorder
Paper Details
References
  • References23
  • Citations2
123

Responses of proximal tubular cells to injury in congenital renal disease: fight or flight

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association

Apr 1, 2014

Robert L ChevalierBarbara A Thornhill

PMID: 23949631

DOI: 10.1007/s00467-013-2590-9

Abstract

Most chronic kidney disease in children results from congenital or inherited disorders, which can be studied in mouse models. Following 2 weeks of unilateral ureteral obstruction (UUO) in the adult mouse, nephron loss is due to proximal tubular mitochondrial injury and cell death. In ne...read more

Mentioned in this Paper

Mitochondrial Toxicity
Cell Death
Mutant
Cyst form of protozoa
Chronic Kidney Insufficiency

Related Papers

Paper Details
References
  • References23
  • Citations2
123

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