Responses of Purkinje cells in the oculomotor vermis of monkeys during smooth pursuit eye movements and saccades: comparison with floccular complex

Journal of Neurophysiology
Ramanujan T Raghavan, Stephen G Lisberger

Abstract

We recorded the responses of Purkinje cells in the oculomotor vermis during smooth pursuit and saccadic eye movements. Our goal was to characterize the responses in the vermis using approaches that would allow direct comparisons with responses of Purkinje cells in another cerebellar area for pursuit, the floccular complex. Simple-spike firing of vermis Purkinje cells is direction selective during both pursuit and saccades, but the preferred directions are sufficiently independent so that downstream circuits could decode signals to drive pursuit and saccades separately. Complex spikes also were direction selective during pursuit, and almost all Purkinje cells showed a peak in the probability of complex spikes during the initiation of pursuit in at least one direction. Unlike the floccular complex, the preferred directions for simple spikes and complex spikes were not opposite. The kinematics of smooth eye movement described the simple-spike responses of vermis Purkinje cells well. Sensitivities were similar to those in the floccular complex for eye position and considerably lower for eye velocity and acceleration. The kinematic relations were quite different for saccades vs. pursuit, supporting the idea that the contributions fr...Continue Reading

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Citations

Apr 18, 2018·Nature Neuroscience·David J HerzfeldReza Shadmehr
Jul 12, 2018·Journal of Neurophysiology·Clara BourrellyLaurent Goffart
Jan 16, 2020·Journal of Neurophysiology·Adi LixenbergMati Joshua
Jul 10, 2018·The Cerebellum·Martha L StrengTimothy J Ebner
Nov 7, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ari A Shemesh, David S Zee

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