PMID: 11311897Apr 20, 2001Paper

Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors

Neuropharmacology
J M LairdF Cervero

Abstract

Tachykinin NK2 receptors are implicated in nociception and the control of intestinal motility. Here we examined their involvement in responses of spinal lumbosacral neurons with colon input to distension of normal or inflamed colon in anesthetized rats. The responses of single neurons to colorectal distension (5-80 mmHg), to electrical stimulation of the pelvic nerve (bypassing sensory receptors) and to somatic stimulation were characterized. The effect of cumulative doses of an NK2 receptor antagonist, MEN 11420 (10-1000 microg kg(-1) IV), on responses to these stimuli was tested in control conditions (n=6), or 45 min after intracolonic instillation of acetic acid (n=6). After colonic inflammation, neuronal responses to colorectal distension and pelvic nerve stimulation were significantly greater. MEN 11420 dose-dependently inhibited the enhanced responses to colorectal distension after inflammation (ID50=402+/-14 microg kg(-1)), but had no significant effect on responses to pelvic nerve stimulation or distension of the normal colon, suggesting a peripheral action selective for the inflamed colon. We conclude that MEN 11420 possesses peripheral anti-hyperalgesic effects on neuronal responses to colorectal distension. These res...Continue Reading

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Citations

Nov 8, 2001·European Journal of Pharmacology·R Patacchini, C A Maggi
Feb 11, 2005·Current Opinion in Gastroenterology·Robin C Spiller
Apr 28, 2005·Journal of Gastroenterology and Hepatology·Alicia S Smith, Scott D Smid
Apr 8, 2003·Drugs·Vincenzo StanghelliniRoberto Corinaldesi
Feb 22, 2011·Gastroenterology Clinics of North America·Robin C Spiller
Aug 28, 2007·Pharmacology & Therapeutics·Anneke RijnierseAletta D Kraneveld
Mar 24, 2004·British Journal of Pharmacology·Alessandro LecciCarlo Alberto Maggi
Mar 31, 2004·British Journal of Pharmacology·Pierangelo Geppetti, Marcello Trevisani
May 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SimpsonR C Spiller
Jan 5, 2002·Expert Opinion on Investigational Drugs·A FarhadiA Keshavarzian
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Alessandro Lecci, Carlo Alberto Maggi
Apr 18, 2008·European Journal of Pharmacology·Aletta D KraneveldJohan Garssen
Nov 27, 2009·Expert Opinion on Investigational Drugs·Laura QuartaraCarlo A Maggi
Jan 20, 2007·Autonomic Neuroscience : Basic & Clinical·Cormac T Taylor, Stephen J Keely
Jan 6, 2018·Journal of Clinical Medicine·Maria Giuliana Vannucchi, Stefano Evangelista
Sep 14, 2004·Journal of Neurobiology·Fernando Cervero, Jennifer M A Laird
Jun 1, 2013·Biomolecular Concepts·Maria Giuliana Vannucchi, Stefano Evangelista
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth H KampG F Gebhart
Oct 9, 2020·Cellular and Molecular Neurobiology·Olga A LyubashinaSergey S Panteleev

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