Responses of Saccharomyces cerevisiae Strains from Different Origins to Elevated Iron Concentrations

Applied and Environmental Microbiology
Carlos Andrés Martínez-GaraySergi Puig

Abstract

Iron is an essential micronutrient for all eukaryotic organisms. However, the low solubility of ferric iron has tremendously increased the prevalence of iron deficiency anemia, especially in women and children, with dramatic consequences. Baker's yeast Saccharomyces cerevisiae is used as a model eukaryotic organism, a fermentative microorganism, and a feed supplement. In this report, we explore the genetic diversity of 123 wild and domestic strains of S. cerevisiae isolated from different geographical origins and sources to characterize how yeast cells respond to elevated iron concentrations in the environment. By using two different forms of iron, we selected and characterized both iron-sensitive and iron-resistant yeast strains. We observed that when the iron concentration in the medium increases, iron-sensitive strains accumulate iron more rapidly than iron-resistant isolates. We observed that, consistent with excess iron leading to oxidative stress, the redox state of iron-sensitive strains was more oxidized than that of iron-resistant strains. Growth assays in the presence of different oxidative reagents ruled out that this phenotype was due to alterations in the general oxidative stress protection machinery. It was notewo...Continue Reading

References

Nov 27, 1999·The Journal of Biological Chemistry·X Z ChenM A Hediger
Jun 8, 2001·The Journal of Biological Chemistry·L LiJ Kaplan
Jul 4, 2002·The Journal of Biological Chemistry·Brian M Waters, David J Eide
Dec 12, 2003·Molecular Biology of the Cell·Minoo Shakoury-ElizehCaroline C Philpott
Jan 13, 2006·Analytical Biochemistry·Jordi TamaritJoaquim Ros
Aug 29, 2006·Bioresource Technology·Maja PasPeter Raspor
Dec 12, 2007·Molecular and Cellular Biology·Liangtao LiJerry Kaplan
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Frank WiensRainer Spanagel
Feb 13, 2009·Nature·Gianni LitiEdward J Louis
Aug 27, 2009·Chemical Reviews·Craig D Kaplan, Jerry Kaplan
Jan 26, 2011·Molecular Ecology·Francisco A CubillosGianni Liti
Feb 7, 2012·Biochimica Et Biophysica Acta·Caroline C PhilpottAvery G Frey
May 23, 2012·Biochimica Et Biophysica Acta·Roland LillUlrich Mühlenhoff
Jul 10, 2012·Cell Metabolism·Yueh-Jung LeeGuillaume F Chanfreau
Aug 22, 2013·Current Opinion in Microbiology·Caryn E Outten, Angela-Nadia Albetel
Oct 22, 2013·G3 : Genes - Genomes - Genetics·Hana N LeeRachel B Brem
Jun 25, 2014·Molecular and Cellular Biology·Nerea SanvisensSergi Puig

❮ Previous
Next ❯

Citations

Jun 19, 2018·PLoS Genetics·Lucía Ramos-AlonsoMaría Teresa Martínez-Pastor
Aug 24, 2018·Metallomics : Integrated Biometal Science·Lucía Ramos-AlonsoSergi Puig
Mar 21, 2017·World Journal of Microbiology & Biotechnology·María Teresa Martínez-PastorSergi Puig
Oct 6, 2020·Frontiers in Microbiology·Lucía Ramos-AlonsoSergi Puig
Jun 15, 2019·Journal of Fungi·Peter J Brechting, Chad A Rappleye
Jul 3, 2021·Biomolecules·Karolina NowosadMarta Arczewska
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gordon A WalkerRon C Runnebaum
Dec 16, 2020·Metallomics : Integrated Biometal Science·Antônio Jesus Dorighetto CogoAnna L Okorokova-Façanha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.