Responses of spinothalamic lamina I neurons to maintained noxious mechanical stimulation in the cat

Journal of Neurophysiology
D Andrew, A D Craig

Abstract

Noxious mechanical stimuli that are maintained for minutes produce a continuous sensation of pain in humans that augments during the stimulus. It has recently been shown with systematic force-controlled stimuli that, while all mechanically responsive nociceptors adapt to these stimuli, the basis for such pain can be ascribed to A-fiber rather than C-fiber nociceptors, based on distinctions in their respective response profiles and stimulus-response functions. The present experiments investigated whether similar distinctions could be made in subsets of nociceptive lamina I spinothalamic tract (STT) neurons using similar maintained stimuli. Twenty-eight lamina I STT neurons in the lumbosacral dorsal horn of barbiturate-anesthetized cats were tested with noxious mechanical stimuli applied with a probe of 0.1 mm(2) contact area at forces of 25, 50, and 100 g for 2 min. The neurons were classified as nociceptive-specific (NS, n = 14) or polymodal nociceptive (HPC, n = 14) based on their responses to quantitative thermal stimuli. The NS neurons had greater responses and showed less adaptation than the HPC neurons in response to these stimuli, and they encoded stimulus intensity better. Comparison of the normalized response profiles o...Continue Reading

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Citations

Jul 15, 2005·Journal of Neurophysiology·Kimberly J DoughertyShawn Hochman
Jun 7, 2008·Cerebral Cortex·Barry L WhitselMark Tommerdahl
Mar 26, 2003·Annual Review of Neuroscience·A D Bud Craig
Dec 17, 2002·The Journal of Physiology·David Andrew, A D Bud Craig
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dieter KleinböhlRupert Hölzl
Apr 1, 2004·Brain Research·Tatiana F AlmeidaSergio Tufik
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Nov 24, 2005·The Journal of Comparative Neurology·Esther Marije KlopGert Holstege
Jul 29, 2008·Current Opinion in Supportive and Palliative Care·Richard M Gordon-Williams, Anthony H Dickenson
Jan 13, 2009·Der Nervenarzt·S Lanz, C Maihöfner
Mar 6, 2003·The Journal of Comparative Neurology·David AndrewA D Bud Craig
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig

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