Responses of spinothalamic lamina I neurons to repeated brief contact heat stimulation in the cat

Journal of Neurophysiology
A D Craig, David Andrew

Abstract

It was recently shown that repeated heat stimulation, using brief contacts (<1 s) with a preheated thermode at sufficiently short interstimulus intervals (ISIs <5 s) and high temperatures (> or =51 degrees C), will elicit in humans a sensation of rapidly augmenting "second" (burning) pain with only a weak "first" (sharp) pain sensation. Most strikingly, at short intertrial intervals (ITIs >5 s) such summation will reset, or begin again at baseline. In the present experiments, the responses of nociceptive lamina I spinothalamic (STT) neurons in the lumbosacral dorsal horn of barbiturate-anesthetized cats were examined using this repeated brief contact heat paradigm. The neurons were classified as nociceptive-specific (NS, n = 8) or polymodal nociceptive (HPC, n = 8) based on their responses to quantitative thermal stimuli; all had receptive fields on the glabrous ventral hindpaw. A pneumatic piston was used to apply a thermode preheated to 34, 46, 49, 53, or 58 degrees C with a contact dwell time of approximately 0.7 s to the ventral hindpaw repeatedly (15 times) at ISIs of 2, 3, and 5 s, with 3-5 min between trials. The mean responses of the 16 nociceptive lamina I STT cells showed rapid temporal summation that was directly dep...Continue Reading

References

Jul 1, 1977·The Journal of Investigative Dermatology·D D Price, R Dubner
Sep 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·R A MackenzieA K Lethlean
Aug 1, 1985·The Journal of Physiology·A D Craig, K D Kniffki
Oct 31, 1983·Brain Research·W J SchadyJ L Ochoa
Mar 15, 1980·The Journal of Comparative Neurology·R M BecksteadR Norgren
Jul 8, 1994·Science·A D Craig, M C Bushnell
Nov 21, 1996·Nature·A D CraigM C Bushnell
Dec 1, 1996·Journal of Neurophysiology·J O Dostrovsky, A D Craig
Jan 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·W D Willis, K N Westlund
Apr 1, 1997·Brain Research. Brain Research Reviews·L B Wilson, G A Hand
Nov 1, 1996·Pain·F Cervero, J M Laird
Jan 14, 1999·The American Journal of Physiology·M P Rosas-ArellanoJ Ciriello
Apr 9, 1999·Nature Neuroscience·Z S HanA D Craig
Jul 1, 1999·The Medical Clinics of North America·M O Urban, G F Gebhart
Jan 29, 2000·Nature Neuroscience·A D CraigE M Reiman
Mar 29, 2000·Progress in Brain Research·C B Saper
Feb 7, 2001·Annual Review of Psychology·L R Watkins, S F Maier
Feb 15, 2001·Nature Neuroscience·H D CritchleyR J Dolan
Dec 4, 2001·The Journal of Physiology·D Andrew, A D Craig
Mar 6, 2002·Journal of Neurophysiology·L B WilsonA D Craig

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Citations

Jul 15, 2005·Journal of Neurophysiology·Kimberly J DoughertyShawn Hochman
Jun 7, 2008·Cerebral Cortex·Barry L WhitselMark Tommerdahl
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Eduardo P M ViannaDaniel Tranel
Jan 1, 2010·Pain Research and Treatment·Fong WongAndre P Mauderli
Mar 26, 2003·Annual Review of Neuroscience·A D Bud Craig
Sep 15, 2015·Human Brain Mapping·Rachael L BosmaPatrick W Stroman
May 4, 2011·Annals of the New York Academy of Sciences·A D Bud Craig
Apr 3, 2003·The European Journal of Neuroscience·Jason R PotasRichard Bandler
Aug 25, 2004·European Journal of Pain : EJP·Gary B RollmanKevin S Jones
Dec 17, 2002·The Journal of Physiology·David Andrew, A D Bud Craig
Nov 1, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dieter KleinböhlRupert Hölzl
Dec 20, 2016·ELife·Junichi HachisukaSarah E Ross
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Apr 22, 2008·Cephalalgia : an International Journal of Headache·J CosteR Dallel
Jul 30, 2002·Nature Neuroscience·H OlaussonM C Bushnell
Jul 29, 2008·Current Opinion in Supportive and Palliative Care·Richard M Gordon-Williams, Anthony H Dickenson
Feb 6, 2019·The Journal of Physiology·Julien Allard
Dec 13, 2006·Pain·Roland StaudDonald D Price
May 15, 2013·Pain·Charles J VierckMark Tommerdahl
Dec 19, 2012·Pain·Charles J VierckMark Tommerdahl
Oct 19, 2016·Pain·Elizabeth M Goudie-DeAngelisAlice A Larson
Sep 12, 2018·Brain Sciences·Jocelyn M PowersPatrick W Stroman
Jul 28, 2020·NeuroImage·Rosa M Sanchez PanchueloOleg Favorov
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig
Jul 2, 2011·ACS Chemical Neuroscience·Kush N Patel, Xinzhong Dong

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