Responses of the nerve cell body to axotomy

Neurosurgery
Peter M RichardsonXuenong Bo

Abstract

Peripheral nerve injury causes retrograde changes in the damaged neurons, which are beneficial to axonal regeneration. Better understanding of the mechanisms of induction and mediation of these conditioning responses would help to design strategies to invoke stronger regenerative responses in neurons in situations when these responses are inadequate. Relevant literature is reviewed. Experimental preparations that measure the influence of peripheral axotomy on regeneration in the central axons of primary sensory neurons are useful to examine mechanisms of conditioning neurons. Despite 4 decades of speculation, the nature of the damage signals from injured nerves that initiate axonal signals to the nerve cell body remains elusive. Members of the family of neuropoietic cytokines are clearly implicated, but what induces them is unknown. Multiple changes in gene regulation in axotomized neurons have been described, and dozens of growth-associated genes have been identified: neurotrophic factors, transcription factors, molecules participating in axonal transport, and molecules active in the growth cone. The mechanisms of interaction of a few regeneration-associated molecules with the signaling cascades that lead to actin and tubulin ...Continue Reading

References

Jul 1, 1973·Archives of Neurology·I G McQuarrie, B Grafstein
Sep 29, 1970·Brain Research·B G Cragg
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Jan 1, 1970·Brain : a Journal of Neurology·P J Wilson
May 1, 1993·Journal of Neurocytology·X Lu, P M Richardson
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black
Oct 6, 2000·Journal of Neurobiology·X P Zhang, R T Ambron
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Hall, C D Nobes
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A FlügelF W Schwaiger
Jan 13, 2001·Current Opinion in Immunology·S Gallucci, P Matzinger
Jul 31, 2001·Nature Neuroscience·N InagakiK Kaibuchi
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Mark P EttingerHans-Peter Guler
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William B J CaffertyStephen W N Thompson
May 25, 2004·Nature Medicine·Damien D PearseMary Bartlett Bunge
Jan 18, 2005·Cell·Takeshi YoshimuraKozo Kaibuchi
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jin QiuStephen W N Thompson
Mar 23, 2005·Current Opinion in Cell Biology·Juan Carlos Arévalo, Moses V Chao
Dec 2, 2005·Nature·Stuart McLaughlin, Diana Murray
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sidney H-K HsiehAlyson E Fournier
Jan 24, 2006·Nature Reviews. Neuroscience·Timothy M Gomez, James Q Zheng
Aug 11, 2006·Journal of Neurochemistry·Shlomit Hanz, Mike Fainzilber
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tizong MiaoPeter M Richardson
Feb 17, 2007·Current Opinion in Cell Biology·Claire R Weston, Roger J Davis
Feb 22, 2007·Nature Reviews. Neuroscience·Nariko Arimura, Kozo Kaibuchi
May 25, 2007·Nature Reviews. Cancer·Weigang WangJohn Condeelis
Jul 6, 2007·The European Journal of Neuroscience·Floor J StamJoost Verhaagen
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rhona SeijffersClifford J Woolf

❮ Previous
Next ❯

Citations

Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John E GreerJohn T Povlishock
Sep 16, 2011·Regenerative Medicine·Edward C TollMartin A Birchall
Jul 13, 2014·Neurosurgical Review·Matthew J BartonDavid A Mahns
Mar 29, 2011·Annual Review of Neuroscience·Kai LiuZhigang He
Oct 19, 2010·Progress in Neurobiology·Ronald DeumensGary A Brook
Mar 15, 2018·Annals of Neurology·Jenna-Lynn B SengerChristine A Webber
Oct 6, 2010·The Journal of Cell Biology·Xin XiongCatherine A Collins
Oct 17, 2018·Neural Regeneration Research·Xuenong Bo
Jan 8, 2021·Frontiers in Neuroscience·Joseph R LoverdeBryan J Pfister
Feb 8, 2019·Experimental Neurology·Jenna-Lynn SengerChristine A Webber

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Annual Review of Neuroscience
J L Goldberg, B A Barres
Annual Review of Neuroscience
Michael P Coleman, Marc R Freeman
© 2022 Meta ULC. All rights reserved