PMID: 11902335Mar 21, 2002Paper

Responses of the rat immune system to arthritogenic adjuvant oil

Scandinavian Journal of Immunology
L SvelanderJ C Lorentzen

Abstract

T-cell mediated inflammatory joint diseases with similarities to rheumatoid arthritis (RA) can be triggered in arthritis-prone rat strains by intradermal injection of adjuvant oils. The pathogenesis of oil-induced arthritis (OIA) remains elusive, and a largely unresolved question is how the rat immune system responds to arthritogenic oils such as incomplete Freund's adjuvant (IFA). Here we report that IFA already induces increased plasma levels of the acute-phase reactants (APR) fibrinogen and alpha1-acid glycoprotein at day 4 postinjection (p.i). In contrast, no early responses were detected in the joints before infiltration of the T cells, which coincided with arthritis onset at 11-14 days post injection (d.p.i.) The infiltrating cells were possibly derived from draining lymph nodes (LN), which were hyperplastic and contained increased cell numbers from 4 days p.i. and onwards. The magnitude of the early increase in cell numbers and APR was regulated by non-major histocompatibility complex (MHC) genes, as determined by comparison between arthritis-susceptible DA rats and arthritis-resistant but MHC-identical LEW.lAV1 and PVG.1AV1 rats. Arthritisprone DA rats developed a weak acute-phase response, suggesting that this systemic...Continue Reading

References

May 1, 1995·International Journal of Immunopharmacology·S KleinauL Klareskog
Jan 1, 1993·Arthritis and Rheumatism·G W CannonM L Woods
May 3, 1996·Cell·M FeldmannR N Maini
Jun 1, 1997·Immunology·L SvelanderS Kleinau
Jan 23, 1998·Veterinary Immunology and Immunopathology·A LarssonC Lundberg
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C LorentzenH Luthman
Feb 19, 1999·Scandinavian Journal of Immunology·J C Lorentzen
Jun 15, 2000·The American Journal of Pathology·B C CarlsonJ C Lorentzen

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Citations

Feb 27, 2004·Occupational and Environmental Medicine·A Reckner OlssonG Wingren
Jun 16, 2004·Clinical and Experimental Immunology·B C HolmA Bucht
Nov 7, 2006·Scandinavian Journal of Immunology·T MiletićM Dimitrijević
Jan 20, 2004·Arthritis and Rheumatism·Lena SvelanderAnders Bucht
Nov 19, 2010·The Journal of Bone and Joint Surgery. American Volume·Bryan T JarrettHenrik Malchau

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