Responses to ALK Inhibitor Treatments in a Patient with Non-Small Cell Lung Cancer Harboring a Novel HPCAL1-ALK Fusion Variant: A Case Report

OncoTargets and Therapy
Ruixiao WangWenzhong Su

Abstract

Anaplastic lymphoma kinase (ALK) fusion is present in approximately 2-7% of patients with lung adenocarcinoma. ALK fusion-positive patients can benefit from targeted therapy. We herein report a 53-year-old Chinese male patient diagnosed as lung adenocarcinoma with a smoking history. Next-generation sequencing was performed to detect somatic mutations of oncogenic drivers and tumor suppressor genes in plasma-derived circulating tumor DNA using an ultra-deep 160-gene panel. A novel HPCAL1-ALK fusion variant was identified in the patient responding to ALK inhibitor treatments, and the fusion variant was also confirmed by fluorescence in situ hybridization and immunohistochemical. Our study expands the mutational spectrum of ALK fusion variants and provides options for the precise treatment of such patients.

References

Aug 14, 2009·The Journal of Biological Chemistry·Jian FuAndres J Klein-Szanto
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sai-Hong Ignatius OuA John Iafrate
Jun 4, 2013·The New England Journal of Medicine·Alice T ShawPasi A Jänne
Mar 29, 2014·Cancer Discovery·Luc FribouletJeffrey A Engelman
Dec 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yonglong ZhangJie Liu
Jun 2, 2016·The Oncologist·Ibiayi Dagogo-Jack, Alice T Shaw
May 6, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dong-Wan KimD Ross Camidge
Jun 7, 2017·The New England Journal of Medicine·Solange PetersUNKNOWN ALEX Trial Investigators
Jan 13, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jason N RosenbaumEric J Duncavage
Feb 8, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne McLeer-FlorinSylvie Lantuejoul
Jun 10, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christian RolfoDavid R Gandara
Jul 4, 2018·Nature Reviews. Clinical Oncology·Christopher AbboshCharles Swanton
Nov 30, 2018·Cancer Discovery·Alexander DrilonMyung-Ju Ahn
Mar 8, 2019·Journal of Cellular and Molecular Medicine·Dongming ZhangBing Liu
Mar 30, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jiayue QinXiangquan Kong
Dec 6, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Yong LiHai-Bo Zhang
Feb 6, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Danielle CohenTom van Wezel

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Methods Mentioned

BETA
biopsy

Software Mentioned

integrative genomics viewer
IGV

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