PMID: 6104699May 1, 1980Paper

Responses to arachidonic acid and other dilator agonists and their modification by inhibition of prostaglandin synthesis in the canine hindlimb

The Journal of Pharmacy and Pharmacology
E Morcillo

Abstract

The influence of indomethacin, in doses that completely inhibit the response to arachidonic acid, has been examined on canine hindlimb vascular responses to intra-arterial administration of bradykinin, histamine, nitroglycerin, isoprenaline and papaverine. The hindlimb was perfused at constant flow. Dose-response curves to intra-arterial administration of arachidonic acid (12 to 200 microgram kg-1), bradykinin (0.4 to 100 ng kg-1), histamine (1.8 to 120 ng kg-1), nitroglycerin (15 to 100 ng kg-1), isoprenaline (12 to 100 ng kg-1) and papaverine (1.2 to 160 microgram kg-1) (all n = 4) were compared before and 30 min after indomethacin (5 mg kg-1 i.v.). All the drugs produced dose-related decreases in hindlimb perfusion pressure. After indomethacin, responses for all dilator agonists except arachidonic acid, were significantly greater than control (P less than 0.05), both in terms of absolute (mmHg) or percent change. Dose-response curves after indomethacin had a left upward shift compared with control. Arachidonic acid responses were completely blocked by indomethacin. These findings suggest that indomethacin produces a non-specific increase in responsiveness of the hindlimb vascular bed to dilator substances, except arachidonic...Continue Reading

References

Oct 25, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·H Juan
Feb 1, 1977·British Journal of Pharmacology·T M FitzpatrickJ C Rose
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P NeedlemanG R Marshall
Jul 1, 1972·Circulation Research·J C McGiffA J Lonigro

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Citations

Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J W ChowT J Chambers

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